ISSN:
1432-0584
Keywords:
Plasma cell leukemia
;
Cell free protein synthesis
;
Immunoglobulin synthesis
;
Effect of BCNU
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary During the clinical course of a secondary plasma cell leukemia the cellular protein synthesis and immunoglobulin synthesis were measured in a cell-free system prepared from peripheral plasma cells. After treatment with cyclophosphamide and a combination of cyclophosphamide with melphalan and vincristine no change in the activity of total protein synthesis was found. In contrast, a decrease of total protein synthesis could be observed after treatment with BCNU combined with cyclophosphamide and Ara-C. The relative amount of 10–15% Ig-synthesis remained unchanged under the different chemotherapeutic regimes. These findings suggest a primary effect of BCNU on cellular protein synthesis in myeloma cells similar to that reported in HeLa cell cultures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01007959
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