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  • 1975-1979  (5)
  • 1950-1954
  • 1940-1944
  • 1930-1934
  • Micropuncture  (3)
  • Renal blood flow  (3)
  • Acid secretion  (1)
  • 1
    ISSN: 1435-2451
    Schlagwort(e): Selective proximal vagotomy ; Pyloric stenosis ; Pyloroplastic ; Gastric emptying ; Acid secretion ; Serum gastrin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Mit einer modifizierten intestinalen Perfusion- und Aspirationsmethode wurden simultan die motorischen and sekretorischen Magenfunktionen nach Gabe einer flüssigen Testnahrung beim wachen Miniaturschwein nach experimenteller Pylorusstenose, alleiniger SPV, SPV mit zusätzlicher Pylorusstenose und SPV mit zusätzlicher Pyloroplastik untersucht. Nach alleiniger SPV fand sich eine initial betonte Abnahme des intragastralen Volumens und eine normale Entleerung in das Duodenum. Bei einer zusätzlichen Pylorusstenose trat keine signifikante Änderung ein. Eine Pyloroplastik führte zu einer signifikanten Anhebung des intragastralen Volumens mit verzögerter Entleerung. Die durch eine SPV reduzierte postprandiale Säuresekretionsleistung wurde weder durch eine Pyloroplastik, noch durch eine Pylorusstenose signifikant verändert. Das basale Serumgastrin war sowohl nach SPV als auch nach SPV in Kombination mit einer Pylorusstenose oder Pyloroplastik erhöht. Nach Nahrungsstimulation kam es zu einem verzögerten Anstieg des Serumgastrins nach SPV, der sich lediglich in der ersten Stunde von den Werten nach SPV mit Pylorusstenose oder Pyloroplastik unterschied. Die vorliegenden Ergebnisse lassen erkennen, daß bei einer SPV durch eine zusätzliche Pyloroplastik keine weitere Verbesserung der sekretorischen und motorischen Funktionen erzielt wird. Weiterhin lassen die erhobenen Untersuchungen den Schluß zu, daß nach SPV mit einer zusätzlichen experimentellen Pylorusstenose keine Entleerungsverzögerung des Magens auftritt und die postoperative Säuresekretion und das Serumgastrin nicht negativ beeinflußt werden.
    Notizen: Summary In conscious fullgrown minipigs simple SPV alone, SPV and pyloric stenosis and SPV and pyloroplasty were performed. After a liquid test meal the motoric and secretory function of the stomach were examined simultaneously by a modified method of intestinal perfusion and aspiration. After simple SPV initially a marked decrease of gastric volume and normal emptying into the duodenum were found. With additional pyloric stenosis no significant change was found. The pyloroplasty lead to an increase of gastric volume and delayed emptying. The acid secretion after feeding reduced by SPV was not changed significantly neither by pyloroplasty nor by pyloric stenosis. The baseline values of serum gastrin were elevated after SPV as well as after SPV in combination with pyloric stenosis or pyloroplasty. After food stimulation there was a delayed increase of gastrin after SPV which differed from that after SPV with pyloric stenosis or pyloroplasty only during the first hour. These results show that after SPV no further improvement of the motoric and secretory function can be achieved by an additional pyloroplasty. Furthermore these findings permit the conclusion that even after SPV with additional artificial pyloric stenosis no delayed gastric emptying occurs and that there is no negative effect postoperatively on the acid secretion and gastrin production.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 289-292 
    ISSN: 1432-1912
    Schlagwort(e): Renal transport ; Dopamine ; β-Adrenoreceptors ; Micropuncture ; Renal blood flow
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The renal effects of dopamine were studied using clearance and micropuncture techniques in rats. Intravenous infusion of dopamine (4.7 · 10−6 mol · kg−1 · h−1) increased glomerular filtration rate and renal blood flow. Renal blood flow was measured by an electromagnetic flowmeter. The increase in filtered fluid and sodium was nearly completely matched by increased tubular reabsorption. Thus, only a small rise in urine flow and in urinary sodium excretion was observed. The micropuncture experiments using the split oil droplet method of Gertz demonstrated a stimulation of the transepithelial fluid transfer after injection of dopamine (10−4M) into the proximal tubular lumen. This effect was abolished by simultaneous injection of propranolol (10−3 M) which, by its own, did not affect transtubular volume fluxes. It is concluded that dopamine, by stimulation of β-adrenoceptors, may increase reabsorptive capacity of the proximal tubular epithelium independent of changes in renal hemodynamics.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Pflügers Archiv 365 (1976), S. 81-87 
    ISSN: 1432-2013
    Schlagwort(e): Renal failure ; Micropuncture ; Diuretics ; Glomerular filtration rate ; Effective filtration pressure ; Renal blood flow
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The renal effects of furosemide in acute renal failure of the rat were studied using clearance and micropuncture techniques. Acute renal failure was induced by an intramuscular injection of 50% glycerol (10 ml/kg). Functional impairement of the glycerol treated animals consisted of a decrease in urinary sodium excretion, renal blood flow, total kidney GFR and effective filtration pressure of superficial nephrons. Effective filtration pressure was calculated from proximal free flow and stop flow pressure measurements. In contrast to control animals furosemide did not increase urine volume during acute renal failure due to a marked fall in GFR. Renal blood flow, as measured by an electromagnetic flowmeter, also decreased after furosemide in glycerol treated rats and increased in control animals. Furosemide reduced effective filtration pressure during acute renal failure to almost zero, whereas in control animals effective filtration pressure virtually remained constant.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 301 (1977), S. 139-143 
    ISSN: 1432-1912
    Schlagwort(e): Renal function ; Renal blood flow ; Glomerular filtration rate ; Urine volume ; Urinary sodium excretion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effects of the competitive angiotensin II antagonist saralasin (1-sarcosine-8-alanine-5-isoleucine-angiotensin II) on renal function in healthy rats and in rats with myohemoglobinuric acute renal failure were studied. Acute renal failure was induced by an intramuscular injection of 50% glycerol (10 ml ·kg−1). Functional impairment of the glycerol treated animals consisted in a decrease of renal blood flow (electromagnetic flowmeter) and GFR and in an increase of urine volume and arterial blood pressure. In healthy rats saralasin (6 μg·kg−1·min−1 i.v.) had no renal effects by itself but antagonized the angiotensin II (200 ng·kg−1·min i.v.) induced fall of renal blood flow and GFR and the increase of arterial blood pressure. Given to glycerol treated animals saralasin did not induce any change of arterial blood pressure, renal blood flow, GFR or the urinary excretion of fluid and sodium.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 304 (1978), S. 289-296 
    ISSN: 1432-1912
    Schlagwort(e): Diuretics ; Clearance technique ; Micropuncture ; Tubular function
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effects of ozolinone (3-methyl-4-oxo-5-piperidino-thiazolidine-2-ylidene) on renal tubular and glomerular functions were studied in rats using clearance and micropuncture techniques. Ozolinone (50 mg·kg−1 i.v., 50 mg·kg−1·h−1i.v.) markedly increased urine volume, urinary sodium excreation and — to a minor extent — also urinary potassium excretion. Fractional tubular sodium reabsorption fell by 14%. Renal blood flow, as measured by an electromagnetic flowmeter, increased considerably during the administration of the drug. Despite the fact that ozolinone increased intratubular hydrostatic pressure, whole kidney as well as single nephron GFR—measured at different tubular sites — remained constant due to an increase in glomerular capillary pressure (stopped flow measurements, servo nulling technique). The diuretic decreased intrinsic reabsorptive capacity of the proximal tubular epithelium as measured with the shrinking drop technique of Gertz, but had no clearcut effects on proximal fractional reabsorption. Fractional reabsorption was evaluated not only from free flow endproximal tubular fluid to plasma inulin measurements but also from transit time and half time of reabsorption (shrinking drop technique). An impressive depression of fluid, sodium and potassium reabsorption occurred in the loops of Henle after ozolinone. No further inhibition of fluid and sodium reabsorption in the distal convoluted tubules could be detected after the drug using a free flow recollection technique. Concerning the tubular site of renal action there is a striking similarity between ozolinone and the strong acting diuretic furosemide, although the chemical structures of these drugs are quite different. Differences between the two drugs exist concerning the endproximal tubular chloride concentration, which was decreased by furosemide but was not affected by ozolinone. This points to different effects of the drugs on proximal tubular bicarbonate reabsorption.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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