ISSN:
1433-8580
Keywords:
Gammaglobulin elimination
;
i.v. Gammaglobulin
;
β-Propiolactone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Dog IgG was produced by fractionation procedures used for the production of clinically used i.v. gammaglobulins. Chemical modification of dog IgG was done by pepsin orβ-propiolactone treatment. The intravascular half-life ofβ-propiolactone IgG was 8.5 ± 2.1 days compared to 4.5 ± 1.6 days of pepsin treated IgG. Tissue concentrations of radioactive labelledβ-propiolactone IgG were generally higher than of pepsin digested IgG. Pepsin treated IgG was degraded to a significantly higher extent (26% of the administered radioactivity was bound to fragments smaller than 6000 MW after three days) thanβ-propiolactone IgG (9% fragments after the same interval,P 〈 0.001). It is concluded that the short intravascular half-life of pepsin IgG cannot be explained by increased extravascular filling, but is due to rapid degradation and excretion via the kidneys. There was no obvious difference in elimination and organ distribution between standard andβ-propiolactone IgG.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01851492
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