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  • 1
    Electronic Resource
    Electronic Resource
    Kinetic analysis of the reversible folding reactions of small proteins: Application to the folding of lysozyme and cytochrome c (1977)
    New York : Wiley-Blackwell
    Biopolymers 16 (1977), S. 731-747 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A general kinetic analysis for unimolecular three-species models is presented. Criteria are established for each model in order to allow selection among alternative models on the basis of their amplitude behavior. These criteria are applied to the previously reported kinetic data for the folding transitions of lysozyme and cytochrome c in guanidine hydrochloride. The degree of success in applying these criteria is found to depend on the extent to which the apparent rate constants, λ1 and λ2, approach each other in certain conditions. Ikai and Tanford have presented a similar kinetic analysis, although these authors considered only the case where no intermediate kinetic species was populated initially. For one protein system, namely, ribonuclease A (RNase A), at least one stable intermediate exists after unfolding outside of the equilibrium transition zone. The criteria developed by Ikai and Tanford cannot be applied to RNase A kinetics and, therefore, a more general analysis is presented. Previously published studies of the reversible folding kinetics of lysozyme and cytochrome c are reexamined using the current amplitude analysis, and it is found that both of these folding transitions can be described by the three-species model, \documentclass{article}\pagestyle{empty}\begin{document}$$ U_{1} \rightleftharpoons U \rightleftharpoons N $$\end{document} used previously to describe the folding kinetics of RNase A (U1 and U2 are two forms of unfolded enzyme and N is the native species). These results suggest that this three-species model may provide a fairly general description of the reversible folding kinetics of small proteins. As an outgrowth of the current analysis, several suggestions for experimental design in studying protein folding will be presented and discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1977.360160404
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  • 2
    Electronic Resource
    Electronic Resource
    Defense Allomones of the Nudibranch Phyllidia varicosa Lamarck 1801 (1979)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 62 (1979), S. 2484-2494 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The defensive secretion of the nudibranch Phyllidia varicosa consists of two isocyanosesquiterpenes: the previously described 9-isocyanopupukeanane (1), and its 2-isomer (4), for which we report the structure and properties. The mixture originates with a sponge, Hymeniacidon sp., where it is produced in varying proportions. CD. measurements and X-ray diffraction data establish the absolute configuration of the two metabolites.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19790620742
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  • 3
    Electronic Resource
    Electronic Resource
    Identification de stérols à chaînes latérales courtes dans l′éponge Damiriana hawaiiana‘Minor and Trace sterols in Marine Invertebrates’, Partie 4, Partie 3: [1]. (1978)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 61 (1978), S. 1470-1476 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Identification of short side chain sterols in the sponge Damiriana hawaiianaThe steroidal composition of the sponge Damiriana hawaiiana is examined. Twenty-seven components are identified. In addition to the C26-C29, Δ5-mono and diunsaturated sterols, the sponge contains sterols without side-chain: androsta-5, 16-dien-3β-ol(1), androst-5-en-3β-ol(2); sterols with a non-functionalized side-chain consisting of two, three, four, five and six carbon atoms: pregna-5, 20-dien-3β-ol(5), pregn-5-en-3β-ol(6), 23, 24-bisnor-chola-5, 20-dien-3β-ol(7), 23, 24-bisnor-chol-5-en-3β-ol(8), 24-nor-chol-5-en-3β-ol(10), chol-5-en-3β-ol(11), 26, 27-bisnor-cholest-5-en-3β-ol(12), and sterols possessing a short oxygenated side-chain such as 3β-hydroxy-androst-5-en-17-one(3), androst-5-en-3β, 17β-diol(4) and 3β-hydroxy-26, 27-bisnor-22-trans-cholesta-5, 22-dien-24-one(14). The probable biological or dietary origin rather than artifact production of these hitherto undescribed components from marine sources is supported by their relatively high concentration and their relative proportions, both very different from those expected for autoxidation.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19780610431
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  • 4
    Electronic Resource
    Electronic Resource
    Die Konformation linearer Makromoleküle (Nobel-Vortrag) Copyright © The Nobel Foundation 1975. - Wir danken der Nobel-Stiftung, Stockholm, für die Genehmigung zum Druck dieser Übersetzung. (1975)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 87 (1975), S. 787-797 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19750872203
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  • 5
    Electronic Resource
    Electronic Resource
    Struktur eines Bimetall-Ethylen-Komplexes: [(C6H5)2NiC2H4]2Na4(THF)5 (1976)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 88 (1976), S. 52-53 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19760880206
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  • 6
    Electronic Resource
    Electronic Resource
    Predicting toughness of impact thermoplastics from high-speed tensile data (1975)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 15 (1975), S. 538-543 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A photographic procedure is presented for evaluating uniaxial true stress-true strain tensile behavior of thermoplastics at strain rates typical of impact situations. The advantage of combining this information with observed macroscopic material changes which occur during tensile deformation is discussed in terms of establishing parameters which define end use abuse resistance of impact thermoplastics. In particular, test parameters are evaluated which provide a direct correlation with measured bottle drop failure resistance for selected materials. These test parameters are obtained by measuring the area under true stress-true strain curves obtained at impact strain rates. Area is measured up to the point of ultimate uniaxile tensile strain. Ultimate uniaxial tensile strain corresponds to either (a) strain at onset of necking in materials which produce necking during deformation, or (b) strain at fracture in materials which deform without necking. Measured test parameters are discussed in terms of modern theories of strength of materials. Pitfalls associated with quantitatively defining the abuse resistance of thermoplastics based on total energy for breaking, i.e., conventional numeric criterion of impact strength, it also discussed.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760150710
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  • 7
    Electronic Resource
    Electronic Resource
    Synthesis of oligomeric group IVA ferrocene polyesters (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 20 (1976), S. 2255-2258 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Oligomeric Group IVA ferrocene Polyesters were synthesized utilizing the interfacial condensation technique. Yield decreases with increasing complexity of the aliphatic substituent; it decreases in the order of I 〉 Br 〉 Cl, and it decreases in the order of Sn 〉 Ge 〉 Si. Thus, initial attack by the nucleophile, steric requirements, and metal - halide bond breakage appear important: Where M = Si, Ge, or Sn.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1976.070200821
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  • 8
    Electronic Resource
    Electronic Resource
    5α-24-Norcholestan-3β-ol and (24Z)-Stigmasta-5,7,24(28)-trien-3β-ol, Two New Marine Sterols from the Pacific Sponges Terpios zeteki and Dysidea herbaceaPart XI in the Stanford series “Minor and Trace Sterols in Marine Invertebrates”. For X: see [1]. (1979)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 62 (1979), S. 101-109 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The steroidal components of 2 marine sponges, Terpios zeteki (from Hawaii) and Dysidea herbacea (from Australia) were fractionated through a combination of chromatographic methods, including reversed phase HPLC., and were analyzed by a combination of physical methods, including high resolution GC.-MS. and 360 MHz 1H-NMR. T. zeteki contains 6 conventional 5α-stanols which comprise 91% of the sterol mixture, and traces (0.5%) of a new C26 sterol, 5α-24-norcholestan-3β-ol. Minor amounts of conventional Δ5-sterols (6.5%) and of a single Δ4-3-ketosteroid (1.5%) were also present. In contrast, the Australian sponge (D. herbacea) contains 3 Δ5,7-sterols which comprise 1.5% of the sterol mixture, and one new C29 sterol, (24 Z)-stigmasta-5,7,24(28)-trien-3β-ol, as the major component (75%). In addition, minor amounts of conventional 5α-stanols (0.5%), Δ5-sterols (5%) and 5α-Δ7-sterols (18%) were present in this complex sterol mixture. The possible dietary or endosymbiotic origins of these sterols are discussed.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19790620115
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  • 9
    Electronic Resource
    Electronic Resource
    The mass spectra of (trimethylstannyl)x methanes: Occurrence of tin-carbon double bonds (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1975), S. 18-25 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of (Me3Sn)nCH4-n, where n varies from 1 to 4, (Me3Sn)2CClX, where X equals H, Cl, Br or I, together with some tetraalkyltin compounds and Me3SnCCl3, are presented. Comparisons with mass spectra of the silicon analogs1 show a large number of similarities, including the appearance of allylic ions which require Group IV metal to carbon π-bonding. Multiple rearrangements are observed with the halogenated tin compounds which bring the α-halogen into direct bonding with the tin atom.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210100104
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  • 10
    Electronic Resource
    Electronic Resource
    On the chemical ionization reactions of alkyl substituted cyclopropanes (1978)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 13 (1978), S. 272-274 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: As predicted by semi-empirical molecular orbital calculations, the methane chemical ionization mass spectra of alkylcyclopropanes exhibit both proton addition and hydride abstraction processes; both the calculations and the observed substituent effects suggest the common intermediacy of gas phase cyclopropylcarbinyl cations. In agreement with this hypothesis are the results of an isotopic labeling experiment which identifies the reactive site as the cyclopropylcarbinyl carbon.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210130508
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