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  • 1975-1979  (4)
  • Tardive dyskinesia  (3)
  • Analytical Chemistry and Spectroscopy  (1)
  • 06A12
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Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Tardive dyskinesia and psychotropic drug history (1978)
    Springer
    Psychopharmacology 58 (1978), S. 117-124 
    Details
    ISSN: 1432-2072
    Keywords: Tardive dyskinesia ; Neuroleptics ; Dosage ; Sex ; Age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The adult population of a large mental hospital was screened for tardive dyskinesia (TD). Approximately 11% of the hospital population showed signs of TD; females and the elderly were over-represented in the TD group. A representative sample of those with TD was selected and a control (non-TD) patient was chosen to match each of the TD subjects in age, sex, length of hospitalization, diagnosis, and race. The charts of these subjects were searched for any indices of brain damage and the complete psychotropic medication history was recorded. There was no difference between the TD and controls in the amount of psychotropics ingested, in the duration of administration, in the kinds of drugs, or in the organicity history. Women as a group, however, tended to have more polypharmacy than men. The role of neuroleptics in TD is discussed as well as other possible etiological factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426893
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clozapine in tardive dyskinesia (1978)
    Springer
    Psychopharmacology 56 (1978), S. 75-80 
    Details
    ISSN: 1432-2072
    Keywords: Clozapine ; Schizophrenia ; Tardive dyskinesia ; Parkinsonism ; Neutropenia ; Convulsions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clozapine, which has had limited clinical testing in the U.S.A., was evaluated in 12 chronic schizophrenic patients with tardive dyskinesia. Its antipsychotic activity was again demonstrated and it suppressed the symptoms of tardive dyskinesia with a marked rebound occurring in these symptoms when it was withdrawn; there was no rigidity or other Parkinsonian symptoms. However, out of a total of 12 patients, neutropenia (800 and 1120) occurred in two patients, convulsions in one patient, marked withdrawal effects in three patients, and a hypotensive collapse with atrial fibrillation in one patient. If these adverse effects are confirmed in a larger sample size, then despite the novel desirable effects of clozapine it would seem unlikely that it will gain widespread or routine use1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571412
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Deanol in the treatment of tardive dyskinesia (1977)
    Springer
    Psychopharmacology 52 (1977), S. 257-261 
    Details
    ISSN: 1432-2072
    Keywords: Tardive dyskinesia ; Deanol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ten hospitalized chronic psychotic patients with symptoms of tardive dyskinesia were given deanol and placebo, each for 8 weeks following a double blind, crossover design. No psychotropic agents were administered during the trial. Improvement occurred in all patients during the first treatment phase regardless of which drug the patients received; seven patients were on deanol and three on placebo during this time. The possible reasons for this decrease were discussed. It was concluded that deanol may have contributed to the decline but that its effect on the disorder was not dramatic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426709
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A selective and sensitive assay for urinary metanephrine and normetanephrine using gas chromatography mass spectrometry with selected ion monitoringAbbreviation: MN = metanephrine; NMN = normetanephrine; PFP = pentafluropropionyl; VMA = vanillymandelic acid; E = epinephrine; NE = norepinephrine; TFA = trifluoroacetyl; MEK = methyl ethyl ketone; PFPA = pentafluoropropionic anhydride; THAM = [tris-(hydroxymethyl)aminomethane]; COMT = catechol-O-methyltransferase; MT = methoxyramine. (1978)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 5 (1978), S. 704-708 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Vapor phase methodology for quantitative analysis of urine for metanephrine and normetanephrine as the pentafluoropropionyl derivative is described. The use of selected ion monitoring provided sufficient sensitivity and selectivity that milliliter aliquots of urine required only a simple scheme of sample processing; preliminary purification consisted of percolation through a column of XAD-2 followed by solvent extraction. The sample extracts were converted to the pentafluoropropionyl derivatives and analyzed by gas chromatography mass spectrometry with selected ion monitoring. Quantitative analysis was based on α[2H2]-β-[2H1]metanephrine and α-[2H2]-β-[2H1]normetane phrine which were added to the urine sample at the outset. The calibration plots for metanephrine and normetanephrine were linear from 10 ng ml-1 to 2000 ng ml-1 of urine permitting the detection of metanephrine and normetanephrine levels throughout the normal range and well into the subnormal range. Examples of application of the methodology to clinical investigation are described. The overall reproducibility of the sample processing methodology and instrumentation was assessed by replicate analyses of the same urine sample over a period of several weeks; the coefficient of variation was ±2.5% (n = 8).
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200051213
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    Paper (German National Licenses)
    Fulltext
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