ISSN:
0306-042X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The methoxime derivatives of N-acyl prostaglandin E2 carboxamides (PG imides), when analyzed in the presence of excess N,O-bis(trimethylsilyl)trifluoroacetamide by gas chromatography, were converted to nitriles and trimethylsilyl esters. For example, the methoximetrimethylsilyl (MO-TMS) derivative of N-acetyl PGE2 carboxamide was converted to the MO-TMS derivative of 9-keto-11,15-dihydroxy-prost-5,13-dienonitrile and the MO-TMS derivative of PGE2. The ratio of rearrangement products was found to be dependent upon the nature of the N-acyl group, and the rearrangement apparently took place in the vapor phase after silylation of the imide moiety.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200060510
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