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Anticonvulsant action of cannabis in the rat: Role of brain monoamines (1978)

Ghosh, P. ; Bhattacharya, S. K.

Springer

Psychopharmacology 59 (1978), S. 293-297

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ISSN: 1432-2072

Keywords: Cannabis indica ; Anticonvulsant action ; Brain monoamines

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The role of brain monoamines in the anticonvulsant action of Cannabis indica resin (CI), against maximal electroshock-induced seizures in albino rats, was investigated by using pharmacologic agents that influence brain monoamine activity. Delta-9-tetrahydrocannabinol content of cannabis resin was estimated to be 17%. The anticonvulsant action of CI (200 mg/kg, i.p.) was significantly inhibited after pretreatment with drugs that reduce brain serotonin activity but not by drugs that reduce brain catecholamine activity. Similarly, the anticonvulsant action of a subanticonvulsant dose (50 mg/kg, i.p.) of CI was potentiated by serotonin precursors but not by catecholamine precursors. Potentiation of the anticonvulsant action of CI by nialamide or by imipramine was inhibited after pretreatment with 5,6-dihydroxytrypt-amine. The results suggest that the anticonvulsant action of CI in the rat is serotonin- and not catecholamine-mediated.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00426637

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Orbital optimization techniques: Comparative study in a semiempirical framework (1978)

Adnan, S. S. Z. ; Bhattacharya, S. ; Mukherjee, D.

New York, NY : Wiley-Blackwell

International Journal of Quantum Chemistry 14 (1978), S. 289-297

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ISSN: 0020-7608

Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: In this paper, MC-SCF and CI methods have been explored for the calculation of ground- and excited-state energies of some aromatic heterocycles in the PPP framework. A new algorithm for solving the orbital equations in MC-SCF theory has been suggested and its performance has been compared with the conventional gradient optimization technique. Energies of first few transitions have been calculated and compared with rather extensive CI results.

Additional Material: 1 Ill.