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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of natural products 47 (1984), S. 377-378 
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of currently available anti-arthritic gold preparations to inhibit lysosomal glycosidases from rheumatoid synovial fluid and normal human serum was studied in vitro. It was shown that these preparations differ markedly in their ability to inhibit the enzymes. Gold thioglucose (Solganal) did not inhibit β-glucuronidase (β-GLUC), β-N-acetylglucosaminidase (β-NAG) or hyaluronidase (HASE). Chloro(triethylphosphine)gold (SK&F 36914) was a potent inhibitor of β-NAG only. Sodium aurothiomalate (Myochrysine and sodium 3-aurothio-2-propanol-1-sulphonate (Allyochrisine) were inhibitors of all three enzymes, notably β-GLUC. Kinetic analysis of inhibition by aurothiomalate demonstrated apparent competitive inhibition with β-GLUC, but non-competitive inhibition with HASE and β-NAG β-GLUC was also strongly inhibited by silver and copper thiomalates. The concentrations of these drugs required for effective inhibition of lysosomal glycosidases probably exceed those attained in serum and therefore preclude this action extracellularly. It is suggested that durg sequestration and retention within phagocytic cells facilitates inhibition of glycosaminoglycan catabolism that mediates cleavage of glucuronidic linkages of hyaluronic acid and chondroitin sulphates. The hypothesis that gold dompounds act in vivo by attenuating the activity of lysosomal enzymes is discussed in relation to these and previous findings.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 38 (1982), S. 629-630 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Antiserum was raised against an aminophenyl derivative of D-mannose grafted on to a liposomal surface. As characterized by immunodiffucion, quantitative precipitation and hapten inhibition, the antiserum was found to contain mannose specific antibodies in addition to antibodies against the aromatic phenyl group.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Lung 87 (1936), S. 720-722 
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Schlußfolgerungen 1. Mittels derLoewensteinschen Züchtungsmethode gelingt es leicht, aus infektiösem Material Tuberkelbacillen zu kultivieren, auch in Fällen, bei denen die bisherigen Färbemethoden versagen. 2. Diese Kulturergebnisse vonLoewenstein und meine eigenen Versuche sprechen viel eindringlicher für die Existenz einer invisiblen Form des Tuberkelbacillus als die Filtrationsversuche. Die genaue Darstellung der Züchtungsmethode aus infiziertem Material sowie Nährbodenbereitung ist inLoewensteins Buch „Die Tuberkelbacillämie in ihrer Auswirkung auf die Gesamtmedizin” Verlag Deuticke, Wien-Leipzig 1936, angegeben.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 102 (1918), S. 205-205 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ON examining even the most regularly split and transparent pieces of mica by diffuse reflected light, a few fine hair-like and rather irregular lines may generally be seen running along the surface. We have found that these lines or striæ show some very interesting effects when mica is examined ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 174 (1954), S. 934-934 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In a collection of the Indian emmer "wheats (khapli) at the Indian Agricultural Research Institute, New Delhi, two distinct races have been discovered differing from each other with respect to certain characters. These are shown in Table 1. The two types also differ cytologically in having either ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 123 (1929), S. 413-414 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] OF late the question of the permanent dipole moment of polyatomic molecules has been considered of great importance in order to elucidate the nature of forces that interact between the constituent atoms of the molecules. The electric moments of a number of primary and secondary alcohols ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 107 (1921), S. 362-362 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] I HAVE read with considerable interest Dr. Houstoun's letter on Young's experiment in NATURE of April 28, p. 268, and I beg to state that we have been using the spectrometer for some time in the University College of Science, Calcutta. For making the double slit, a rectangular slit, about 2 cm. ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 115 (1925), S. 230-230 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] OF the various methods of determining surface tension of liquids, the method of ripples is free from all surface influences. Lord Rayleigh, Dorsey, Gr¨nmach, Kalähne and others have determined the surface tension of water by this method. Grünmach applied the same method in determining the ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 124 (1929), S. 230-230 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN a note recently communicated to NATURE it was pointed out that the Raman effect in triatomic molecules having a linear model could be explained on the assumption of a fundamental mode of vibration along the line joining the three nuclei of the molecules. Such vibrations take place along the ...
    Type of Medium: Electronic Resource
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