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  • 1975-1979  (4)
  • Nictitating Membrane  (2)
  • Bacteriology  (1)
  • Endoscopy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Die Dickdarmanastomose und ihre Abheilung unter massiver Bakterienkontamination (1976)
    Springer
    Langenbeck's archives of surgery 341 (1976), S. 1-9 
    Details
    ISSN: 1435-2451
    Keywords: Single- and double-layer anastomosis of the intestine ; Staphylococcus aureus contamination ; Bacteriology ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 30 Ratten wurde der Heilungsvorgang der Colonanastomose nach massiverStaphylococcus aureus Kontamination untersucht. Die Tiere erhielten je eine einreihige und eine zweireihige Naht in einer Sitzung. Während der Operation wurden die Anastomosen mit hochvirulentenStaphylococcus aureusKeimen besiedelt. Alle Tiere wurden nach 1, 2, 3 und 4 Tagen sowie nach 2 1/2 Wochen getötet. Neben dem allgemeinen klinischen Verlauf wurden die Anastomosen nach folgenden Kriterien beurteilt: 1. Sichtbare Absceßbildung. 2. Insuffizienzen. 3. Bakteriologische Untersuchungen mit Feststellung des Keimgehaltes. 4. Histologische Untersuchungen. Nach sichtbaren Entzündungsreaktionen mit Adhäsionen und Absceßbildungen in den ersten postoperativen Tagen mit einem Maximum am 4. postoperativen Tag waren nach 2 1/2 Wochen alle Anastomosen verheilt, dicht und staphylokokkenfrei. Bei der feingeweblichen Untersuchung zeigte sich ein deutliches Überwiegen entzündlicher Reaktionen und Absceßbildungen in der frühen postoperativen Phase bei der zweireihigen Nahttechnik.
    Notes: Summary In 30 rats the healing process of colonic anastomosis contaminated withStaphylococcus aureus was studied. At the same time on each animals a single- and double-layer anastomosis was performed. All sutures were infected during the surgical procedure with highly infectiousS. aureus. The rats were sacrificed after 1, 2, 3, 4 days, and 2 1/2 weeks. Criteria for estimation were mainly visible abscess formations, leakage spots, bacteriologic and histologic examinations. After apparent inflammatory reactions were seen on the first postoperative days with a maximum on the 4th day, all sutures were completely healed and free ofS. aureus after 2 1/2 weeks. As for the extent of infectious inflammation, the single-layer suture technique proved to be more resistant than the double layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01261733
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition by dopamine of 3H-noradrenaline release elicited by nerve stimulation in the isolated cat's nictitating membrane (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 289 (1975), S. 179-203 
    Details
    ISSN: 1432-1912
    Keywords: Nerve Stimulation ; Noradrenaline ; Dopamine ; Nictitating Membrane ; Neurotransmission ; α-Adrenoceptors ; Dopamine Receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After loading the isolated nerve-muscle preparation of the cat nictitating membrane with 3H-(±)-noradrenaline the effects of exogenous dopamine and (-)-noradrenaline were determined on 3H-transmitter overflow elicited by nerve stimulation in the presence of cocaine, 29 μM. Dopamine, 0.20 μM, and (-)-noradrenaline, 0.18 μM, inhibited 3H-noradrenaline release elicited by nerve stimulation at 4 or 10 Hz. Similar results were obtained with apomorphine 0.03 or 0.1 μM. Chlorpromazine, 1 μM, or pimozide, 1 μM, antagonized selectively the reduction in 3H-noradrenaline release obtained with dopamine or apomorphine, without affecting the inhibition obtained with (-)-noradrenaline. Phentolamine, 1 μM, antagonized more effectively the inhibitory effects of (-)-noradrenaline than those of dopamine. Phenoxybenzamine, 0.29 μM, prevented the inhibition of 3H-transmitter overflow obtained with (-)-noradrenaline, dopamine or apomorphine. In the absence of cocaine neither chlorpromazine nor pimozide were able to increase 3H-transmitter overflow during nerve stimulation. In contrast to these results, block of α-adrenoceptors by phentolamine or phenoxybenzamine resulted in an increase 3H-transmitter overflow during nerve stimulation. Inhibition by dopamine of 3H-transmitter overflow appears to be mediated through dopamine receptors probably located in the outer surface of adrenergic nerve endings. These dopamine receptors differ from the prejunctional α-adrenoceptors that mediate the negative feed-back regulatory mechanism for noradrenaline release by nerve stimulation. The prejunctional inhibitory dopamine receptors are not involved in an endogenously mediated regulatory mechanism for noradrenaline release by nerve stimulation under normal conditions. The possibility that these dopamine receptors are involved in the hypotension commonly observed in patients with chronic l-Dopa treatment is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501305
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Selective inhibition by hydrocortisone of 3H-normetanephrine formation during 3H-transmitter release elicited by nerve stimulation in the isolated nerve-muscle preparation of the cat nictitating membrane (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 287 (1975), S. 261-275 
    Details
    ISSN: 1432-1912
    Keywords: Nerve Stimulation ; Noradrenaline Metabolites ; Hydrocortisone ; Extraneuronal Uptake ; Normetanephrine ; Nictitating Membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The metabolism of 3H-noradrenaline released by nerve stimulation in the isolated nerve-muscle preparation of the cat nictitating membrane was determined under control conditions and in the presence of hydrocortisone, 28 μM, a concentration which inhibits the high affinity extraneuronal uptake of noradrenaline in this tissue. in the controls the main fraction in the overflow elicited by stimulation at 10 Hz during 2 min was the deaminated glycol, 3H-DOPEG (3,4-dihydroxyphenylglycol), which accounted for 45.2±2.96% of the total radioactivity. Under these conditions, 3H-noradrenaline represented 30.8±1.92%, while 3H-normetanephrine accounted for 14.5±0.94% of the total overflow of radioactivity. During exposure to hydrocortisone there was a selective inhibition in 3H-normetanephrine formation from 3H-noradrenaline released by stimulation while the other fractions were not affected significantly. In contrast to these results, there were no changes in the spontaneous outflow of 3H-normetanephrine during exposure to hydrocortisone. The results obtained support the view that 3H-normetanephrine in sponteneous release originates from the activity of prejunctional catechol-O-methyltransferase. On the other hand, 3H-normetanephrine formed during transmitter release elicited by nerve stimulation is due to the activity of extraneuronal catechol-O-methyltransferase. Access of 3H-noradrenaline released by nerve stimulation to extraneuronal catechol-O-methyltransferase is mediated through the high-affinity, hydrocortisone-sensitive extraneuronal uptake mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501472
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    228. Abdomino-cervicale Magentransposition (1979)
    Springer
    Langenbeck's archives of surgery 349 (1979), S. 579-579 
    Details
    ISSN: 1435-2451
    Keywords: Esophagus cancer ; Pharyngogastromy ; Endoscopy ; Manometry ; Oesophaguscarcinom ; Abdomino-cervicale Magentransposition ; Endoskopie ; Manometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwischen 1970 und 1978 wurden 76 Patienten mit Oesophaguscarcinom operativ behandelt. Bei 12 Kranken führten wir eine einzeitige, retrosternale Magentransposition als Oesophagusersatzplastik durch. 9 Patienten dieser Gruppe konnten über annähernd 2 Jahre klinisch, endoskopisch und manometrisch nachuntersucht werden. Die Magentransposition erwies sich als ein technisch relativ einfaches Verfahren mit guten funktionellen Ergebnissen.
    Notes: Summary This report concerns our experience in the treatment of 76 patients with carcinoma of the esophagus. 12 of these underwent one-stage pharyngogastrostomy. 9 patients were followed up postoperatively. The investigated parameters were: clinical status, endoscopic and manometric findings. In conclusion: this procedure was found to be a good practicable method with promising functional results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01729688
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    Paper (German National Licenses)
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