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Digitale Medien

Pentose-shunt oxidation in the periosteal cells in healing fractures (1977)

Dunham, Jane ; Shedden, R. G. ; Catterall, A. ; [weitere]

Springer

Calcified tissue international 23 (1977), S. 77-81

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Details

ISSN: 1432-0827

Schlagwort(e): Fracture Healing ; Glucose 6-phosphate ; Dehydrogenase ; Glutathione ; Microdensitometry ; Cytochemistry

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin , Physik

Notizen: Summary The activity of pentose-shunt dehydrogenases is very low in periosteal cells of normal rat metatarsals, but increases one day post-fracture and rises linearly over the next two days. By four days postfracture, the distribution of this activity along the bone shows two centres of high activity: the first in the region of proliferation to form callus and the second at the site where new bone is first seen, one day later. The high rate of generation of NADPH would be expected to reduce glutathione; reduced glutathione has been shown to inhibit alkaline phosphatase activity in these cells.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02012769

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