ISSN:
1432-2072
Keywords:
Conditioned Taste Aversions
;
Amphetamine
;
Fenfluramine
;
Tolerance
;
Cross-Tolerance
;
Drug Abuse
;
Animal Models
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Conditioned taste aversions (C.T.As) established in rats to 0.1% sodium saccharin by intra-peritoneal injections of dl-fenfluramine hydrochloride (6 mg per kg) or d-amphetamine sulphate (2.0 mg per kg) were found to be significantly attenuated, but not abolished altogether, by chronic pretreatment (over 9 days) with the specific drug. Prior treatment with fenfluramine attenuated the aversive effects of amphetamine, but the converse was found not to be the case. These results are considered to refute the “Unnatural need state” and “Novelty” hypotheses of the effects of prior drug experience on the establishment of C.T.As. An alternative explanation of such effects in terms of tolerance is considered, and the possible relevance of the results to studies of drug abuse in humans discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421187
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