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Induction of enzyme-altered islands in rat liver by tryptophan pyrolysis products (1979)

Ishikawa, T. ; Takayama, S. ; Kitagawa, T. ; [et al.]

Springer

Journal of cancer research and clinical oncology 95 (1979), S. 221-224

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ISSN: 1432-1335

Keywords: Enzyme-altered island ; Tryptophan pyrolysis product ; Mutagen

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Two new γ-carboline derivatives, 3-amino-1,4-dimethyl-5H pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H pyrido[4,3-b]indole (Trp-P-2), isolated from the pyrolysis products of tryptophan, were found to be potent mutagens. When weanling rats were injected with Trp-P-1 and then given diet containing phenobarbital, they developed enzyme-altered islands in the liver. Since these islands are considered to be formed by immediate progeny of “initiated cells” and cell precursors in hepatocarcinogenesis, Trp-P-1 may well be carcinogenic in rat liver.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00410642

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