ISSN:
1432-2072
Keywords:
Metoclopramide
;
Pimozide
;
Dopamine Receptors
;
Motor Activity
;
Stereotypy
;
Turning
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Metoclopramide antagonises apomorphine-in-duced stereotypy in rats (ED50 1.5 mg/kg), apomorphine reversal of reserpine-induced locomotor suppression in mice (50% inhibition produced by 17 mg/kg), and apomorphineor amphetamine-induced turning behaviour in mice with unilateral lesions of the striatal dopaminergic nerve terminals (ED50 5.0 and 4.0 mg/kg respectively). Metoclopramide resembles pimozide in all these respects and appears to be a relatively potent antagonist of striatal dopamine receptors. Yet metoclopramide, in anti-emetic doses, has no effect on disability in Parkinson's disease or on the therapeutic benefit of l-Dopa and l-Dopa dyskinesias.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421070
Permalink
