ISSN:
1573-8744
Keywords:
l-dopa
;
plasma half-life
;
plasma clearance
;
total body clearance
;
hepatic clearance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The role of the liver in the plasma clearance of l-dopa in the rat was examined. Some published studies which ascribe an important role to the liver in l-dopa clearance are discussed and critically evaluated. Contrary evidence suggesting that the liver is not a significant site of l-dopa clearance in vivo ispresented. The plasma concentration of l-dopa during intravenous infusion of the drug was not significantly reduced after a single passage through the liver. All of the data discussed are consistent with the conclusion that the liver plays a minor role in l-dopa clearance in vivo.It is suggested that the small intestine is the major site of metabolism of orally administered l-dopa.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01066592
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