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  • 1
    Electronic Resource
    Electronic Resource
    OESTRADIOL PRODUCTION BY HUMAN GRAAFIAN FOLLICLES CULTURED IN VITRO (1978)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 85 (1978), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Intact human Graafian follicles recovered during the preovulatory phase of the menstrual cycle and cultured in vitro, gave a mean oestradiol production of 33 ng/hour over periods of 4 to 92 hours. Treatment of follicles with human pituitary gonadotrophin or human chorionic gonadotrophin resulted in an increased production of oestradiol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1978.tb10484.x
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  • 2
    Electronic Resource
    Electronic Resource
    Dissociation of response to injected gonadotropin between the Graafian follicle and oocyte in pigs (1976)
    [s.l.] : Nature Publishing Group
    Nature 260 (1976), S. 156-158 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mature Large White gilts with 20- or 21-d oestrous cycles were assigned to one of four groups and given a single intramuscular injection of 500 or 1,000 IU of HCG (Organon) in saline on day 17, 18, 19 or 20 of the cycle. Ovulation occurs 40?42 h after such an injection given during prooestrus8,9. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/260156a0
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  • 3
    Electronic Resource
    Electronic Resource
    Studies on the maintenance of porcine graafian follicles in organ culture (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 133-135 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Nous avons étudié les follicules de Graaf dans différents milieux de culture organique classique, le but éventuel étant de voir comment le LH provoque la reprise de la méiose. Les follicules ont été prélevés de l'ovaire de 16 truies se trouvant à différents stades du cycle oestrien et mis en culture sous pression augmentée (0.703 kg/cm2). En général, les couches de cellules et même l'ovocyte supportèrent bien la mode de culture décrit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01924721
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A comparison of the discriminative stimulus properties of R-2,5-dimethoxy-4-methylamphetamine (R-DOM) and S-amphetamine in the rat (1975)
    Springer
    Psychopharmacology 44 (1975), S. 225-228 
    Details
    ISSN: 1432-2072
    Keywords: R-DOM ; S-Amphetamine ; State-dependent discriminative responding ; Generalization of drug-induced stimuli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of 0.75 mg/kg of R-DOM and 1.0 mg/kg of S-amphetamine served as discriminative stimuli in the control of a two-lever discrimination response. Dose-response evaluation of the two agents indicated that in S-amphetamine-trained animals the drug effects produced by test doses of 0.5 to 2.2 mg/kg of S-amphetamine could be considered as a dose-dependent continuum of low to high stimulus intensity. In R-DOM trained subjects, low to moderate doses of R-DOM (0.5–1.5 mg/kg) produced dose-related discriminative responding, but the high dose of R-DOM (2.2 mg/kg) resulted in random responding. When animals trained to discriminate 1.0 mg/kg of S-amphetamine from saline were given 0.5 or 0.75 mg/kg of R-DOM, they tended to respond on the drug correct lever. However, higher doses of R-DOM (1.5 and 2.2 mg/kg) produced random responding. Similarly, animals trained to discriminate 0.75 mg/kg of R-DOM from saline exhibited correct responses following 0.5 and 0.75 mg/kg of S-amphetamine, but not after 1.5 and 2.2 mg/kg. These data suggest that low doses of R-DOM produce discriminative stimuli that are qualitatively different from those of higher doses. Stimuli following low doses of R-DOM also appear similar in some respects to those following low doses of S-amphetamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428898
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  • 5
    Electronic Resource
    Electronic Resource
    Behavioral and neuropharmacological analysis of amphetamine and 2,5-dimethoxy-4-methylamphetamine in rats (1975)
    Springer
    Psychopharmacology 44 (1975), S. 229-239 
    Details
    ISSN: 1432-2072
    Keywords: DOM and amphetamine comparisons ; Operant behavior ; Motor activity ; Brain catecholamines ; Brain serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comparison of the behavioral pharmacology of DOM and amphetamine in rats indicated that lower doses (0.10–1.0 mg/kg) of the two agents had similar effects on schedule-controlled food-reinforced and shock-avoidance behavior. Similarities were also noted in their effects on horizontally directed motor activity when testing was preceded by a period of acclimation. However, most doses of DOM tended to decrease unacclimated motor activity, while amphetamine increased this behavior. Neuropharmacological antagonism studies indicated that brain catecholamines (CA) and serotonin (5-HT) are involved in the behavioral effects of both DOM and amphetamine. Cinanserin, a 5-HT receptor blocker, attenuated the behavioral disruptive effects of both agents on food-reinforced responding. Cinanserin attenuated the effects of all doses of DOM and those of higher doses of amphetamine on shock avoidance. When given prior to lower doses of amphetamine, there was a greater behavioral stimulation than when amphetamine was given alone. Prior depletion of brain CA with α-methyltyrosine (α-MT) did not affect DOM induced disruption of food-reinforced responding, while α-MT attenuated the behavioral effects of all doses of DOM and amphetamine on shock avoidance. These data suggest that DOM and amphetamine share a similar component in their mechanism of action which depends on the availability of a releasable pool of brain CA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428899
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