Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 37 (1977), S. 111-118 
    ISSN: 1432-0533
    Keywords: Ageing ; Dementia ; Neuronal loss ; Neurofibrillary tangles ; Granulovacuolar degeneration ; Hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The number of pyramidal neurones in the hippocampal cortex was determined in serially sectioned mesial temporal lobe from brains of 18 mentally normal people; as well as those of 8 demented patients with pathologically confirmed Alzheimer's disease. Normal ageing was accompanied by a gradual loss of neurones, whereas dements' brains showed a much more severe decrease, exceeding that of controls at any age. A high degree of negative exponential correlation was found between the density of neurones/mm3 of cortex and both the number of neurones with neurofibrillary degeneration and the number with granulovacuolar degeneration. The functional significance of the latter changes is thus probably greater than previously assumed, given the diminished population of surviving neurones in which these alterations appear. Both tangles and granulovacuoles demonstrated a stronger propensity for occurring in the posterior half of the hippocampus in demented patients' brains. This would not have been predicted from the relative distribution of neuronal loss in the two halves. The posterior portion of the hippocampus may be considerably more susceptible to the degenerative nerve cell changes prominent in dementia of the Alzheimer type.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-0533
    Keywords: Aging ; Dementia ; Neurofibrillary tangles ; Granulovacuolar degeneration ; Hippocampus ; Topography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Topographic analysis was performed of the distribution of Alzheimer's neurofibrillary tangles and the granulovacuolar degeneration of Simchowicz in the hippocampal cortex of patients with Alzheimer's dementia and mentally normal aged controls. A semiautomated scanning stage microscope was linked potentiometrically to an XY pen recorder in order to plot cytoarchitectonic “scattergrams” from the sequentially screened hippocampal formations. The density of both lesions per cubic mm of pyramidal cortex was quantified by measuring the area of each of six “zones”, using a digitizer and programmable calculator. In elderly normal brains as well as those of Alzheimer's disease, the statistically most representative ranking order of predilection forneurofibrillary tangles (in decreasing severity) was: entorhinal cortex 〉 subiculum 〉 H1 〉 end-plate 〉 presubiculum 〉 H2. Forgranulovacuolar degeneration the best rank order was: subiculum 〉 H1 〉 H2 〉 end-plate 〉 entorhinal cortex 〉 presubiculum. The notable similarities of both such orders of predilection to the well-recognized “selective vulnerability” of certain hippocampal neurones in clinical conditions of hypoxia, ischemia and epilepsy suggest some common, focally accentuated cytotoxic mechanism may underlie all these regional predispositions.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 37 (1978), S. 27-29 
    ISSN: 1432-0584
    Keywords: Rhesus: Gm groups ; Allelic-association ; Linkage ; British random sample ; Rhesus: Gm groups ; Allelic-association ; Linkage ; British random sample
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An investigation of 1088 unrelated British people to look for an association between alleles of theRhesus blood group system and those of theGm system gave the result expected for totally independent loci.
    Notes: Zusammenfassung Eine Untersuchung von 1088 nicht verwandten Briten zur Prüfung des Zusammenhangs zwischen Allelen des BlutgruppensystemsRhesus und denen desGm- Systems bestätigte vollkommen unabhängige Loci.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...