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  • 1
    Electronic Resource
    Electronic Resource
    Are there somatostatin-containing nerves in the rat gut? Immunohistochemical evidence for a new type of peripheral nerves (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 852-854 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Antibodies to somatostatin, a recently isolated hypothalamic peptide inhibiting growth hormone release, were used in immunohistochemical studies on the gastrointestinal tract. Somatostatin containing cells in the stomach, and somatostatin-containing nerves in the small and large intestine, could be demonstrated. These findings give evidence of a new type of nerve in the gut.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01938502
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Somatostatin in the pancreas, stomach and hypothalamus of the diabetic Chinese hamster (1977)
    Springer
    Diabetologia 13 (1977), S. 463-466 
    Details
    ISSN: 1432-0428
    Keywords: Somatostatin ; diabetic Chinese hamsters ; islet cells ; A1-cells ; glucagon ; insulin ; hypothalamus ; stomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The inhibitory effects of somatostatin on the release of insulin and glucagon, as well as its localization to the A1-cells (D-cells) of the pancreatic islets, suggest a role of this peptide in carbohydrate metabolism. In the present study we have measured the percentage islet volume, the total weight of the A1-cells and the somatostatin concentration in the pancreas of normal and spontaneously diabetic Chinese hamsters. In addition, the concentration of somatostatin in the stomach and hypothalamus as well as the insulin and glucagon content of the pancreas were evaluated. The percentage islet volume in the normal hamsters was 0.66±0.12, which was in marked excess of that in the diabetic group, 0.38±0.04. Similarly, the total weight of the A1-cells in the controls, 0.17±0.02 mg, was significantly larger than that in the diabetic animals, 0.12±0.02 mg. In agreement with these findings there was also a decreased pancreatic concentration of insulin and somatostatin, whereas the glucagon concentration was in the normal range. Also the stomach of the diabetic hamsters showed a decreased concentration of somatostatin. In the hypothalamus the total content of somatostatin appeared similar in the two groups of animals, but when expressed per mg wet weight this value was also decreased in the diabetic hamsters. These observations strongly suggest that, in the diabetic Chinese hamster, apart from the well-known B-cell deficiency there exists also a decreased functional activity of the somatostatin-producing cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01234497
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Somatostatin — both hormone and neurotransmitter? (1978)
    Springer
    Diabetologia 14 (1978), S. 1-13 
    Details
    ISSN: 1432-0428
    Keywords: Somatostatin ; hypothalamus ; hypophysis ; growth hormone ; insulin secretion ; neurotransmitters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429702
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of phentolamine and preperfusion with glucose on insulin release from the isolated perfused pancreas from fasted and fed rats (1975)
    Springer
    Diabetologia 11 (1975), S. 407-410 
    Details
    ISSN: 1432-0428
    Keywords: Insulin release ; perfused pancreas ; fasting ; phentolamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Starvation of rats for 24 hrs resulted in decreased insulin release from the isolated rat pancreas. The effect of fasting could not be counteracted by elevation of the glucose level in the equilibration medium from 0.8 to 1.5 mg/ml. The alpha-adrenergic blocking agent phentolamine (10 μg/ml) stimulated glucose induced insulin release to approximately the same extent in fasted as in fed rats. These findings illustrate the importance of endogenous catecholamines in the regulation of insulin secretion from the isolated pancreas. Our experiments suggest that the impairment of insulin secretion on fasting is due neither to the inhibitory effect of catecholamines nor to the lack of substrate in the pancreas at the initiation of the stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429908
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The empty sella syndrome-intrasellar cisternal herniation-in “normal” patients and in patients with communicating hydrocephalus and intracranial tumors (1978)
    Springer
    Neuroradiology 17 (1978), S. 35-43 
    Details
    ISSN: 1432-1920
    Keywords: Empty sella syndrome ; Intrasellar cisternal herniation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The occurrence of empty sella was studied on 450 pneumoencephalograms. It was not sex dependent, and seemed to be an acquired condition increasing in frequency with age. Empty sella was found in 10% of subjects with otherwise normal encephalograms. The frequency was higher in persons with communicating hydrocephalus (32%), hormoneproducing pituitary tumors (33%) and increased intracranial pressure due to cerebral tumors (18%). In all these subjects empty sella was often accompanied by demineralization and erosion of the sella turcica. Independent of the lumbar pressure, empty sella was most often found in patients with communicating hydrocephalus with only moderately high ventricle index and comparatively increased volume of the third ventricle. Empty sella was also frequent among patients with temporal tumors (32%) causing deformation and displacement of the third ventricle but in whom signs of increased intracranial pressure were lacking. The disturbed anatomy of the third ventricle possibly explains the higher frequency of empty sella in association with these tumors compared to other supratentorial tumors. altogether, these findings indicate that disturbance of the cerebrospinal fluid (CSF) circulation, especially in the third ventricle, with or without established increase of the intracranial pressure, plays an important role in the etiology of empty sella. This is further substantiated by the demonstration that the type of intrasellar herniation could be related to the position of the third ventricle. Neither the type of herniation nor the form of the sella could be related to the presence or absence of a co-existing intracranial tumor or to the location of the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345268
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    Paper (German National Licenses)
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