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  • 1975-1979  (5)
  • 1
    Electronic Resource
    Electronic Resource
    6-Hydroxydopamine destruction of central adrenergic neurones prevents or reverses developing DOCA-salt hypertension in rats (1977)
    Springer
    Journal of neural transmission 40 (1977), S. 149-158 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of brain catecholaminergic neurones in the pathogenesis of DOCA-salt hypertension in the rat was investigated by selective depletion of central catecholamines using intraventricular or intracisternal administration of 6-hydroxydopamine (6-OHDA). Only the intraventricular injections prevented the development of hypertension. In addition, intraventricular 6-OHDA reversed the hypertension produced by two weeks but not six weeks of DOCA-salt treatment. The ability of intraventricular injections of 6-OHDA to prevent or reverse DOCA-salt hypertension while intracisternal injections do not, appears to be related to the greater depletion of brain catecholamines produced by the intraventricular injections. Only in the spinal cord and in the locus coeruleus were the norepinephrine contents depleted equally by either injection route. These findings suggest that central catecholaminergic neurones other than those originating in the locus coeruleus or descending in the spinal cord are important in the initiation, but not in the long term maintenance, of DOCA-salt hypertension. The influence of the central catecholamine neurons involved in the development of DOCA-salt hypertension might be mediated neurally via nonadrenergic pathways or hormonally via the brain-pituitary-endocrine system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250565
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Epilepsy and schizophrenia: A neurochemical bridge (1977)
    Springer
    Journal of neural transmission 40 (1977), S. 159-170 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper reviews some of the evidence in the literature that suggests neurochemical processes by which the regulation of seizure threshold and the onset of schizophrenic-like symptoms are interrelated. For those patients who experience the alternation of seizures and acute psychoses the following working hypothesis is presented: The central dopaminergic synapse is described as a malfunctioning regulatory circuit. Insufficient feedback inhibition or lifting of the setpoint leads to an increased number of occupied receptors. This might cause schizophrenic-like symptoms. Insufficient release of feedback control or lowering of the setpoint leads to a decreased number of occupied receptors. This might increase seizure susceptibility. The neurochemical arguments in support of this hypothesis will be discussed in detail. The localization of the dopaminergic synapses involved in the development of schizophrenic-like symptoms is subject to speculation. The meso-limbic dopaminergic system has to be taken into consideration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250566
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Elevated serum dopamine-β-hydroxylase activity in rats with inherited diabetes insipidus (1975)
    Springer
    Journal of neural transmission 36 (1975), S. 107-112 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activity of dopamine-β-hydroxylase, the enzyme that catalyzes the conversion of dopamine to norepinephrine, was measured in the serum of a strain of Wistar rats homozygous and heterozygous for a genetic form of hypothalamic diabetes insipidus and in Wistar control rats. Serum dopamine-β-hydroxylase activity and water intake was highest in the homozygous affected rats and lowest in normal controls. Treatment with pitressin tannate reduced serum enzyme activity and water intake in rats with diabetes insipidus to levels which did not differ from controls. Thus serum dopamine-β-hydroxylase activity appeared to vary directly with changes in sympathetic nerve activity in response to intravascular volume depletion and repletion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01256758
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Serum dopamine-ß-hydroxylase activity in rat during post-natal development (1976)
    Springer
    Journal of neural transmission 39 (1976), S. 301-307 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rat serum dopamine-β-hydroxylase (DBH) activity is quite high in the immediate post-natal period reaching peak activity (75 units) at 16 days of age. Activity then decreases rapidly over the following weeks to approach adult levels (10 units) by seven weeks of age. Also, specific activity of DBH in heart increased rapidly during the first 2 1/2 weeks of life attaining adult levels by 18 days of age. In contrast, heart weight and total DBH activity in whole heart increased in a coordinate fashion at a relatively constant rate throughout the first seven weeks of life. Serum levels of non-copper sensitive endogenous inhibitor (s) of DBH increased throughout the first seven weeks of life while no change in copper sensitive inhibition was observed. Also, the rapid phase of decrease in serum DBH activity corresponded to the period of the most rapid increase in body weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01266306
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Responses of plasma renin activity and dopamine-beta-hydroxylase to increased intravascular volume (1979)
    Springer
    Journal of neural transmission 46 (1979), S. 35-45 
    Details
    ISSN: 1435-1463
    Keywords: Renin ; dopamine-beta-hydroxylase ; aldosterone ; sodium ; volume expansion ; natriuresis ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Circadian variations of plasma renin activity, plasma dopamine-beta-hydroxylase, and urinary aldosterone excretion were measured in man under conditions of high- and low-sodium intake. Plasma renin activity and urinary aldosterone excretion were maximal at 8 a.m. Plasma DBH shows small, biologically insignificant circadian fluctuations. In three subjects on low-salt diets, the values were lower than those in the same subjects on high-salt diets. Expansion of intravascular volume in supine normal volunteers lowered plasma renin and DBH activity, and also resulted in a significant natriuresis. The decline in DBH activity probably reflects a decrease in its release from autonomic nerve endings and thus demonstrates in man an effect of decreasing autonomic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243427
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    Paper (German National Licenses)
    Fulltext
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