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  • 1975-1979  (5)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Appearance of hCG-receptor after conversion of newborn ovarian cells into testicular structures by H-Y antigen in vitro (1978)
    Springer
    Human genetics 〈Berlin〉 45 (1978), S. 203-207 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In a previous report (Zenzes et al., 1978 b) it was shown that dissociated ovarian cells of newborn rats in vitro, if exposed to H-Y antigen, reorganize into testicular structures. The current study was designed to see whether this morphological conversion also results in a functional conversion. The LH/hCG receptor was used as a parameter characteristic for the newborn testis, but not for the newborn ovary. In the converted ovary, the LH/hCG receptor becomes detectable a few hours after onset of the culture and remains continuously present afterward. The appearance of this receptor may be due to a hormone-like action of H-Y antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286964
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Organization in vitro of ovarian cells into testicular structures (1978)
    Springer
    Human genetics 〈Berlin〉 44 (1978), S. 333-338 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary While it has been shown previously (Zenzes et al., 1978; Ohno et al., 1978) that when dissociated testicular cells are exposed to anti-H-Y antiserum in vitro they are prevented from reorganizing into testicular structures, forming ovarian follicular structures instead, the most conclusive evidence for the action of H-Y antigen would be the conversion of ovarian cells into testicular organization. Testing for H-Y antigen of the medium collected from cultivated testicular cells revealed a positive reaction. Dissociated ovarian cells of newborn rats cultivated in this medium reorganize into testicular structures. It is concluded that H-Y antigen is responsible for this histomorphologic change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00394298
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The testis as a secretory organ for H-Y antigen (1978)
    Springer
    Human genetics 〈Berlin〉 45 (1978), S. 209-213 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary After cultivation of dissociated rat testicular tissues, H-Y antigen is detectable in the medium; this is not the case if nongonadal male tissues are incubated. Release of H-Y antigen by testis cells is inhibited by the addition of cycloheximide. All tissues still type H-Y positive after culture. It is assumed that the testis actively secretes H-Y antigen. This assumption is supported by the finding that the amount of H-Y antigen in the epididymal fluid increases with the age of the animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286965
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Studies on H-Y antigen in different cell fractions of the testis during pubescence (1978)
    Springer
    Human genetics 〈Berlin〉 45 (1978), S. 297-303 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Various cell types of the rat testis during pubescence, including germ, Sertoli, and Leydig cells, were partially enriched. The fractions were tested for the presence, binding, and secretion of H-Y antigen. The main results are: Immature germ cells are H-Y antigen-negative until the late diploid stages, and late primary spermatocytes or spermatids become positive; the somatic cells of the gonad are positive at all ages examined (18 days old to adulthood). Secretion of H-Y antigen is restricted to the Sertoli cell fraction. Binding of externally supplied antigen takes place on Leydig cells; the Sertoli cell surface will be saturated because of active secretion; there is no binding to germ cells. Thus, immature germ cells seem to be the only H-Y antigen-negative cells of the male organism, and the Sertoli cells seem to be the only ones to secrete H-Y antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278727
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Binding studies of H-Y antigen in rat tissues (1978)
    Springer
    Human genetics 〈Berlin〉 43 (1978), S. 151-157 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The binding capacity for H-Y antigen was studied in various rat tissues of both sexes. In nongonadal tissues (liver, kidney, brain, epidermis) binding could not be demonstrated. In contrast, the gonads are able to bind exogenously supplied H-Y antigen. In the ovary, the binding capacity remains unchanged in newborn and adult animals, while in the testis, this capacity decreases with age. A receptor like that of a proteohormone is assumed to exist in the gonads but not in other tissues. In nongonadal tissues, H-Y antigen apparently is present only if the cell itself synthesizes the antigen. The H-Y antigen receptor of the gonads is not sex-specific. Thus, the primary sex differentiation depends on whether H-Y antigen is synthesized in the organism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293592
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    Paper (German National Licenses)
    Fulltext
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