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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 5 (1972), S. 464-470 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 6 (1973), S. 176-180 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— We describe a method for the fluorometric determination of 5-hydroxyindoles in the physiological range of 0.010–1.30 μg/ml of whole blood by means of an autoanalytical procedure. Serotonin is dialysed free from haemolysed blood constituents and a complex between 5-HT and o-phthaldialdehyde is formed in the dialysand to provide a considerable increase over the native fluorescence of 5-HT in strong acid. The method has been evaluated and considered to be accurate for the continuous monitoring of levels of 5-HT in whole blood and for the determination of cerebral arteriovenous differences. The range of values for human patients with cerebrovascular disease was 0.09–0.34 μg/ml of whole blood. In experimental studies on the baboon the range was 0.538–1.28 μg/ml. A mean positive cerebral arteriovenous difference for 5-HT (and possibly other 5-hydroxyindoles) of 0.037 μg/ml was measured in 10 baboons. This finding suggests the possibility of physiological movement of 5-HT and 5-hydroxyindoles into brain across the blood-brain barrier.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 76 (1972), S. 1-9 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 5 (1972), S. 130-132 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 2 (1973), S. 0 
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. Male weanling rats were fed a diet containing 1.3 mg zinc/kg diet and controls the same diet supplemented by 40 mg /zinc/kg diet. The rates of cell division and upward migration in the cheek epithelium were obtained from counts of labelled cells in animals sacrificed one hour and three days following intraperitoneal injection of 1 μCi tritiated thymidine/g body weight. A 3.4-fold increase over the number of labelled cells in controls was observed one hour after thymidine administration and a 2.7-fold increase three days later. Ratios of labelled cells at three days and one hour were 4.96 in controls and 3.99 in experimental animals. The percentage distribution of labelled cells in successive subdivisions of epithelium was identical in both groups. The number of labelled cells near the junction of granular and keratin layers was 2.9-fold greater in the experimental animals.It is suggested that the zinc-deficient cheek epithelium of the rat might be a useful model for the study of pathological conditions associated with increased rates of cell proliferation.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1920
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le flux sanguin cérébral régional, le flux sanguin hémisphérique, le flux sanguin extracrânien et le volume sanguin cérébral régional ont été mesurés chez une série de malades á l'aide de la gamma-caméra munie d'un système de bandes magnétiques pour enregistrement et relecture. Cette méthode élimine la nécessité de multiples essais pour mesurer ces paramètres. Le 133Xe et le 99mTc injectés dans les artères carotides servent d'indicateurs radio-actifs. Ces mesures ont été effectuées chez des patients atteints de ramollissement cérébral, d'hématome intracérébral, de tumeur cérébrale, de malformation artério-veineuse et de démence. Les valeurs du flux sanguin cérébral hémisphérique correspondaient á celles obtenues par la technique de l'embol á hydrogène. Les effets d'inhalateurs de CO2 á 5%, de perfusions intraveineuses de Glycérol et de vaso-dilatateurs sur le flux cérébral régional ont été déterminés et trouvés intéressants pour le point de vue diagnostique et thérapeutique. Des dérivations de sang ont été trouvées chez des malades atteints de lésions expansives (hématomes et tumeurs). Dans le cas de thrombose de la carotide interne, les mesures montrent une augmentation du glux sanguin cérébral régional lorsqu'une intervention par bypass est mise en oeuvre.
    Abstract: Zusammenfassung Nach Injektion von Xe 133 und Tc 99m in die A. carotis wurden der regionale cerebrale Blutdurchfluß und der Hemisphärenblutdurchfluß mit der Gamma-Camera bestimmt. Dabei konnten die gleichen Ergebnisse wie mit den übrigen punktförmigen Messungen nachgewiesen werden.
    Notes: Summary Regional cerebral blood flow (rCBF), hemispheric blood flow (HBF), extracranial blood flow, and regional cerebral blood volume (rCBV) have been measured in a series of patients using a gamma camera equipped with a magnetic tape system for storage and retrieval. This method eliminates the need for multiple probes in measuring these parameters. 133Xe and 99m Tc injected into the carotid arteries were used as radioactive indicators. These measurements were carried out in patients with cerebral infarction, intracerebral hematoma, brain tumor, arteriovenous malformation, and dementia. The HBF values obtained with this method were in excellent agreement with those using the hydrogen bolus method in the same patients. The effects of 5% CO2 inhalation, intravenous infusion of glycerol, and vasodilator drugs on rCBF and rCBV were evaluated and were found useful from diagnostic and therapeutic points of view. “Intracerebral steal” or “intracerebral squeeze” were demonstrated only in patients with space-occupying lesions such as intracerebral hematoma or brain tumor. Cerebral revascularization using a recently developed intracranial bypass procedure for the occluded internal carotid artery was found effective in increasing rCBF in selected cases where the procedure was successful.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 6 (1974), S. 237-245 
    ISSN: 1432-1920
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les mesures du flux sanguin cérébral régional au repos et après technique d'activation furent associées à la sério-angiographie cérébrale chez des malades présentant une hémorragie méningée due à une rupture anévrysmale. Une telle étude était utile dans le choix et l'évaluation de l'efficacité du traitement des facteurs d'aggravation tels que les spasmes cérébraux, l'oedème cérébral, l'hydrocéphalie aigüe et chronique et l'hématome intracébr'ebral. Les valeurs du flux sanguin cérébral régional trouvées furent plus faibles chez des malades après hémorragie méningée, en rapport tant avec l'état neurologique qu'avec les facteurs aggravants mentionnés ci-dessus. Lorsque le spasme vasculaire était levé par la Phénoxybenzamine, le flux sanguin cérébral régional était constant bien que le volume sanguin cérébral régional augmentait, suggérant que d'autres facteurs peuvent être plus importants pour la réduction du flux sanguin céréphalie communiquante. Lorsqu'on traitait l'oedème cérébral et l'hydrocéphalie aigüe soit par Glycerol intra-veineux, soit par drainage lombaire du liquide céphalorachidien, le flux sanguin cérébral régional augmentait.
    Abstract: Zusammenfassung Ausführliche Untersuchungen des CBF in Kombination mit der Serien-Angiographie bei Patienten mit einer Subarachnoideal-Blutung. Dabei sollten die Komplikationsfaktoren, wie Gefäßspasmus, Hirnödem, akuter und chronischer Hydrocephalus, intracerebrales Haematom, bestimmt werden. Der regionale Hirndurchflußwert war bei allen Patienten nach einer Subarachnoideal-Blutung reduziert. Dabei konnte nachgewiesen werden, daß das Hirnödem und der Hydrocephalus eine besondere Bedeutung für die Reduktion des CBF haben. Nach der Behandlung dieser Komplikationen kam es zu einem Anstieg der Hirndurchblutung.
    Notes: Summary Regional cerebral blood flow (rCBF) measurements in the steady state and after activation techniques were combined with serial cerebral arteriography in patients with subarachnoid hemorrhage (SAH) due to ruptured aneurysm. Such information was useful in selecting and evaluating the effectiveness of treatment for complicating factors such as cerebral vasospasm, cerebral edema, acute and chronic hydrocephalus and intracerebral hematoma. Regional cerebral blood flow values were found to be reduced in patients after SAH and correlated well with the neurological status and the complicating factors listed above. When vasospasm was relieved by phenoxybenzamine (PBZ), rCBF did not increase although regional cerebral blood volume did, suggesting that other factors may be more important for the reduction of rCBF such as cerebral edema and communicating hydrocephalus. When cerebral edema and acute hydrocephalus were treated by either intravenous glycerol or lumbar cerebrospinal fluid drainage, RCBF increased.
    Type of Medium: Electronic Resource
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