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  • 1970-1974  (2)
  • 1955-1959
  • 1880-1889
  • Autoradiography  (1)
  • Hypothalamic Thermal Stimulation  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 345 (1973), S. 43-59 
    ISSN: 1432-2013
    Keywords: Temperature Regulation ; Hypothalamic Thermal Stimulation ; Core Temperature ; Continuous Temperature Signals ; Feedback Control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In four conscious goats with chronically implanted hypothalamic thermodes, forty-three experiments were carried out at environmental conditions between +5°C and 30°C DB/18°C WB. The temperature of the hypothalamus was altered by perfusing the thermodes with water whose temperature, as measured at the inlet of the thermodes, varied between 30°C and 43°C. Heat production, respiratory evaporative heat loss, rectal and oesophageal temperatures were measured. Hypothalamic cooling resulted in an elevation of rectal temperature, while hypothalamic heating caused a fall in temperature. The relation between the intensity of hypothalamic thermal stimulation and the induced change in core temperature can be well described by linear regressions. No difference in sensitivity and no dead band between responses to cold and warm stimulation was found. The experiments show that hypothalamic and extra-hypothalamic sensors of core temperature continuously operate at high sensitivity even within the narrow range of physiologically occurring core temperatures. Qualitatively, this sensitivity is independent of air temperatures between +5°C and +30°C.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 146 (1973), S. 309-317 
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Prostaglandin E1 ; Autoradiography ; Electron microscopy ; Lipid analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary To determine whether or not prostaglandins enter adrenocortical parenchymal cells,3H-PGE1 was injected intravenously into rats. In histological preparations, grains denoting activity were noted in intracellular lipid droplets and nuclei and in sinusoids. At the fine structural level, activity was observed in lipid droplets, mitochondria, the agranular endoplasmic reticulum, nuclei and the plasma membrane. Biochemical lipid analyses of the adrenals revealed activity in the cholesterol and cholesterol ester fractions. Large amounts of unaltered3H-PGE1 and its degradation products were also present. Compared to the liver, the adrenal was more effective in degrading prostaglandin, when expressed on a weight basis. The possible roles of the organelles in PGE1 degradation and in prostaglandin-related hormone synthesis are discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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