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  • 1
    Electronic Resource
    Electronic Resource
    α-Sympathicomimetische Eigenschaften als Ursache der blutdrucksteigernden und blutdrucksenkenden Wirkung von BAY 1470 (2-(2,6-Xylidino)-5,6-dihydro-4H-1,3-thiazinhydrochlorid) (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 268 (1971), S. 348-360 
    Details
    ISSN: 1432-1912
    Keywords: Sympathomimetics ; Blood Pressure ; Central Nervous System ; Sympathicomimetica ; Blutdruck ; Zentralnervensystem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Phentolamine antagonizes the pressor response as well as the response of the nictitating membrane of the cat to BAY 1470. After propranolol the pressor response to BAY 1470 is unchanged while that to adrenaline is increased. 2. In concentrations of up to 10−3 g/ml BAY 1470 is devoid of any activity on isolated guinea-pig atria; hence, BAY 1470 does not seem to act onβ-receptors. 3. BAY 1470 has noindirect sympathomimetic effects. Cocaine antagonizes the pressor effect of tyramine but not that of BAY 1470. Pretreatment with reserpine does not reduce the pressor response to BAY 1470. The output of noradrenaline from the spleen does not increase during perfusion with BAY 1470. 4. The initial pressor response to BAY 1470 is followed by a prolonged fall in blood pressure; the latter seems to be due to an inhibition of the release of noradrenaline from the peripheral sympathetic neurones as well as to a central site of action. The peripheral site of action could be demonstrated by a diminished output of noradrenaline from the splenic nerves following electrical stimulation during perfusion with BAY 1470. The central origin of the depressor response has been demonstrated by its occurence during perfusion of the fourth ventricle with BAY 1470. 5. As the depressor response following the ventricular perfusion with BAY 1470 is inhibited by phentolamine and dibenzyline perfusion of the ventricle, the central depressor action seems to be mediated byα-receptors located in the vicinity of the fourth ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997267
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  • 2
    Electronic Resource
    Electronic Resource
    Alpha- und beta-sympathicomimetische Wirkungen am elektrisch gereizten isolierten Meerschweinchenileum (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 195-207 
    Details
    ISSN: 1432-1912
    Keywords: Acetylcholine ; Guinea-pig Ileum ; Morphine ; Sympatholytics ; Sympathomimetics ; Acetylcholin ; Meerschweinchenileum ; Morphin ; Sympathicolytica ; Sympathicomimetica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The contractions of the isolated, electrically stimulated guinea-pig ileum during ganglionic blockade by Hexamethonium are inhibited by BAY 1470 [2-(2,6-Dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine], Morphine, Naphazoline, Isoprenaline, Noradrenaline and Adrenaline. These drugs are approximately equipotent in producing inhibition. 2. The inhibitory effects of Noradrenaline and Isoprenaline are diminished only by Propranolol and those of BAY 1470 and Naphazoline are abolished only by Phentolamine. The inhibitory effect of Adrenaline is diminished both by Propranolol and by Phentolamine. Neither Propranolol nor Phentolamine influence the Morphine induced effect. 3. Noradrenaline and Isoprenaline inhibit the electrically stimulated contractions and the effects of added Acetylcholine to the same extent. BAY 1470, Morphine and Naphazoline diminish only the effect of electrical stimulation and not that of Acetylcholine. Adrenaline inhibits both, but against the electrically induced contractions it is effective in lower concentrations than against the action of added Acetylcholine. 4. The results of these and of preceding investigations indicate that therelease of Acetylcholine from the parasympathetic nerve can be inhibited by stimulatinga-adrenergic, and theaction of Acetylcholine by stimulatingβ-adrenergic mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997092
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  • 3
    Electronic Resource
    Electronic Resource
    Zur Toxikologie der Bakterienendotoxine (1952)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 218 (1952), S. 111-113 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250111
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  • 4
    Electronic Resource
    Electronic Resource
    Central nervous α-adrenergic receptors and the mode of action of α-methyldopa (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 279 (1973), S. 285-300 
    Details
    ISSN: 1432-1912
    Keywords: α-Adrenergic Receptors ; α-Methyldopa ; Catecholamines ; Central Activity ; Central Nervous System ; Blood Pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experiments in cats with perfusion of the fourth and parts of the third cerebral ventricle gave the following results: 1. Perfusions with α-methyldopa, α-methyldopamine, α-methylnoradrenaline, noradrenaline, or tyramine produced a significant decrease of the systemic arterial blood pressure. A dose-response relationship of this effect was demonstrated with noradrenaline and α-methylnoradrenaline. 2. The blood pressure lowering effect of the amines was inhibited or abolished by perfusion with phentolamine or yohimbine. 3. The depressor effect of perfusions with tyramine was inhibited after addition of 2μg/ml cocaine to the perfusion fluid. Cocaine perfusion enhanced the depressor effect of α-methylnoradrenaline. 4. In the reserpine-pretreated cat the effect of tyramine was strongly inhibited. α-Methylnoradrenaline had no effect under these conditions. 5. Perfusions with angiotensin produced an increase of the peripheral blood pressure, while isoprenaline and propranolol showed no significant activity. 6. In the intact anaesthetized, as well as in the spinal, cat the intravenous pressor activities of noradrenaline and α-methylnoradrenaline were nearly identical. The response of the isolated aortic strip of the rat was somewhat more pronounced to α-methylnoradrenaline than to noradrenaline. 7. The results of these investigations are in favour of the hypothesis that in the brain stem an α-receptor mechanism exists, which is able to mediate a blood pressure decreasing effect of centrally applied catecholamines. The central hypotensive action of α-methyldopa may be explained by this mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500607
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  • 5
    Electronic Resource
    Electronic Resource
    Über die Oxydation von Adrenalin und Arterenol (1950)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 212 (1950), S. 142-143 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00245686
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  • 6
    Electronic Resource
    Electronic Resource
    Die Spezifität der Antinicotinwirkung verschiedener Pharmaka am Meerschweinchendarm (1954)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 222 (1954), S. 215-216 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00249319
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  • 7
    Electronic Resource
    Electronic Resource
    Adrenalin-Arterenolwirkungen und Schilddrüsenhormon (1951)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 216 (1951), S. 148-149 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00248071
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  • 8
    Electronic Resource
    Electronic Resource
    Über die Beeinflussung der Thyroxinwirkung durch Ergotamin, Dihydroergotamin und Hydergin beim Meerschweinchen (1952)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 216 (1952), S. 344-352 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Der nach täglicher Verabfolgung von Thyroxin beim Meerschweinchen einsetzende Gewichtsverlust läßt sich durch gleichzeitige Injektion von Ergotamin, Hydergin und Dihydroergotamin hemmen. 2. Im Gegensatz dazu kann man die nach Vorbehandlung mit Thyroxin auftretende Diuresesteigerung durch simultane Vorbehandlung mit den genannten Mutterkornalkaloiden nicht vermindern. An den mit Thyroxin + Hydergin bzw. Dihydroergotamin behandelten Tieren kommt es nach peroraler Belastung mit physiologischer Kochsalzlösung lediglich zu einer 1–2stündigen Verzögerung der Diurese, welche wahrscheinlich auf einer Kreislaufeigenwirkung der Dihydroalkaloide beruht. Danach bricht jedoch die Thyroxinwirkung wieder durch, so daß die in 8 Std ausgeschiedene Flüssigkeitsmenge mit der Harnmenge der Thyroxintiere übereinstimmt. Die Kochsalzdiurese steigt etwa im gleichen Verhältnis an wie die Wasserausscheidung. 3. Die Versuchsergebnisse sprechen dafür, daß die Thyroxinwirkung auf den oxydativen Stoffwechsel in enger Beziehung zu den gesteigerten Funktionen des sympathischen Nervensystems steht, daß dies jedoch für den Mechanismus der diuretischen Thyroxinwirkung nicht zutrifft.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00246677
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  • 9
    Electronic Resource
    Electronic Resource
    Raupin, ein neues Alkaloid aus Rauwolfia serpentina (1953)
    Springer
    Naturwissenschaften 40 (1953), S. 342-342 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00589607
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  • 10
    Electronic Resource
    Electronic Resource
    Neue Alkaloide aus Rauwolfia Serpentina (1953)
    Springer
    Naturwissenschaften 40 (1953), S. 625-625 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00589756
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