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  • 1970-1974  (3)
  • 1915-1919
  • Anticholinergic Activity  (1)
  • Coronary Blood Flow  (1)
  • Hydroxyapatite  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Influence of nitroglycerin on the size of experimental myocardial infarction (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 387-400 
    Details
    ISSN: 1432-1912
    Keywords: Myocardial Infarction ; Coronary Blood Flow ; Epicardial Mapping ; Nitroglycerin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of nitroglycerin (N.G.) on the size of myocardial infarction was studied in 12 open-chest dogs with chloralose-urethane anesthesia by means of epicardial ECG-mapping and compared with the influence of simple ligature of the same coronary artery branch. In order to identify the specific effect of N.G. on the heart and the coronary circulation without contribution of the peripheral circulation in 6 dogs aortic pressure was stabilized by a clamp placed around the descending aorta and heart rate was kept constant by atrial pacing. Nitroglycerin (0.5 mg/kg i.v.) infused during the occlusion period of 20 min resulted in a decrease of mean arterial pressure for 27 mm Hg (p〈0.005) and left ventricular enddiastolic pressure for 2 mm Hg (p〈0.05) indicating a diminishment in oxygen demand. Mean coronary blood flow was reduced to a similar extent (18%) as in the control infarction (22%). Compared to simple occlusion no significant alteration in the extent of ST-elevation in the epicardial electrogram was observed during N.G.-infusion even in the presence of hypotension. In the stabilized group with constant afterload (mean arterial pressure) and heart rate nitroglycerin induced a slight, but not significant decrease of the enddiastolic left ventricular pressure compared to the control group. However, coronary blood flow and ST-elevation were unaffected. Thus, neither in the unstabilized nor in the stabilized group the extent of myocardial injury after ligature of a coronary artery branch were influenced by nitroglycerin. Obviously the improvement in the oxygen demand during nitroglycerin is out balanced by the reduction in oxygen supply so that in effect myocardial infarction size is not altered by N.G. as estimated from epicardial ECG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500998
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A scanning electron microscopic study of the growth of hydroxyapatite crystals (1972)
    Springer
    Calcified tissue international 10 (1972), S. 91-102 
    Details
    ISSN: 1432-0827
    Keywords: Hydroxyapatite ; Calcification ; Phases ; Growth ; Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé La croissance cristalline de l'hydroxyleapatite à 25° et à pH constant de 7.4 a été étudiée à l'aide du microscope électronique à balayage. La technique reproductible de croissance par ensemencement à partir de solutions stables sursaturées est utilisée efficacement pour produire des échantillons de minéral à divers stades distincts de croissance. Des changements de phase sont observés avec le progrès de la croissance; ils correspondent dans le temps avec les résultats cinétiques obtenus antérieurement. Un essai de rationalisation est tenté à la lumière des mécanismes proposés pour la formation d'hydroxyleapatite dans des conditionsin vivo.
    Abstract: Zusammenfassung Das Kristallwachstum von Hydroxyapatit bei 25° und einem konstanten pH von 7,4 wurde mit Hilfe eines Raster-Elektronenmikroskopes studiert. Die reproduzierbare Technik des Keimwachstums aus stabilen übersättigten Lösungen wurde mit Erfolg verwendet, um Mineralproben in verschiedenen bestimmten Stadien des Wachstums zu erhalten. Phasenveränderungen wurden beim fortschreitenden Wachstum beobachtet, und diese stimmten zeitlich gut überein mit kinetischen Resultaten, über welche früher berichtet wurde. Es wurde versucht, diese Beobachtungen zu erklären in Anbetracht von Mechanismen, welche für die Bildung von Hydroxyapatit unterin vivo-Bedingungen vorgeschlagen wurden.
    Notes: Abstract The crystal growth of hydroxyapatite at 25° and at a constant pH of 7.4 has been studied with the aid of a scanning electron microscope. The reproducible technique of seeded growth from stable supersaturated solutions was used effectively to produce samples of the mineral at various distinct stages of growth. Phase changes were observed as the growth proceeded and these corresponded favorably in time with kinetic results reported earlier. An attempt was made to rationalize the observations in light of mechanisms proposed for the formation of hydroxyapatite under conditions foundin vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012539
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Dose responses and relationships between anticholinergic activity and mood with tricyclic antidepressants (1972)
    Springer
    Psychopharmacology 25 (1972), S. 205-217 
    Details
    ISSN: 1432-2072
    Keywords: Imipramine ; Tricyclic Antidepressants ; Salivation ; Anticholinergic Activity ; Mood Change
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A pilot study showed that single doses of imipramine (100 mg) produced a maximum reduction in salivation after 3 h which persisted for 72 h after drug. Effects after 3 h were reproducible in 3 subjects and differed from control levels on all 6 occasions of testing. A double-blind study in 6 subjects was then carried out to ascertain whether a dose response measured by salivary flow could be obtained for imipramine and dimethacrin, a developmental drug with fewer anticholinergic effects in animals. A further objective was to study the effects of both drugs on subjective feelings of mood, appetite, and dry mouth in order to make correlations between these effects and the anticholinergic activity. Results showed a linear log-dose response reduction in salivation for imipramine which differed significantly from placebo and dimethacrin. Significant changes on the Clyde Mood Scale in sleepiness and friendliness factors occurred only with imipramine, raising the question of whether there is a causal relationship between the central actions of imipramine and its anticholinergic activity. The significant decrease in friendliness with imipramine as compared to placebo suggests that anticholinergic activity is unlikely to be responsible for antidepressant effect, but may account for the drug's sedative action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422502
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    Paper (German National Licenses)
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