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  • 1970-1974  (311)
  • Chemical Engineering  (244)
  • Engineering  (54)
  • pharmacokinetics
  • 1
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 430-431 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 4 (1972), S. 49-65 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The application of the high precision triangular plate bending element to problems with curved boundaries is considered. Appropriate edge conditions for nodal points on these boundaries are derived. The error inherent in representing the shape of a curved boundary by a series of straight segments is found to be the limiting factor on accuracy, while the effect of approximations in the actual boundary conditions is minor. To overcome the first type of error, the high precision element is modified to include one curved edge. Substantial improvements in accuracy are obtained, as demonstrated in example calculations for circular and elliptical plates.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 20 (1974), S. 207-207 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 10 (1970), S. 241-246 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The results of a study to determine the biological stability of clear, colorless, biocide-treated PVC film are presented. With the exception of a resistant control, all the PVC film samples tested contained a plasticizer susceptible to biological deterioration. Biocide-treated and control PVC film samples were subjected to biological attack in soil burial. Portions of each sample were exposed to leaching and to weathering in a weatherometer followed by soil burial to test the stability of each biocide to loss by water and weathering exposure. Of the 32 biocide preparations tested only 2, N-(trichloromethylthio) phthalimide and copper 8-quinolinolate, a known effective reference compound, were found to provide good protection for treated film in direct soil burial and in soil burial following leaching and weatherometer exposure. Natural weathering outdoors confirmed the results found with weatherometer exposed samples. The N-(trichloromethylthio) phthalimide was less effective than the reference compound in suppressing surface growth. In addition, N-(trichloromethylthio) phthalimide may not be compatible with all PVC formulations.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 6 (1973), S. 261-267 
    ISSN: 1432-1041
    Keywords: Alclofenac ; antiphlogistic ; man ; pharmacokinetics ; dosage regimes ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A one compartment open model has been found to fit plasma concentration data previously obtained in man after single oral doses of alclofenac; the parameters of the model are: $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ abs=1.3±0.7h, $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ el=3.5±1.2h, Vd/F=17±6. The model has been used successfully to predict steady-state plasma levels of alclofenac after multiple oral doses. One treatment schedule (initial dose 500 mg, maintenance dose 250 mg five times a day) was administered to two volunteers for five days and the plasma levels of alclofenac determined daily. The latter were in good agreement with computer predictions based on the model. It is now possible, therefore, to select the most suitable dosage regimes for this drug.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of pharmacokinetics and pharmacodynamics 1 (1973), S. 89-98 
    ISSN: 1573-8744
    Keywords: clindamycin ; clindamycin-2-palmitate ; clindamycin-2-hexadecylcarbonate ; bioavailability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract To determine the bioavailability of clindamycin from the microbiologically inactive clindamycin-2-palmitate and clindamycin-2-hexadecylcarbonate in man, a three-way crossover study was conducted with oral administration of the two esters and clindamycin hydrochloride. In each case, serum clindamycin bioactivity concentrations were fitted to a one-compartment open model with an initial lag time. Analysis of variance of measured quantities (serum concentrations and urinary excretion) and of derived pharmacokinetic parameters showed that for every comparison except maximum serum concentrations clindamycin-2-palmitate was not significantly different (at p=0.05) from clindamycin hydrochloride. Clindamycin-2-hexadecylcarbonate gave significantly different values from those for the hydrochloride in all cases except the rate constant and half-life for elimination from the serum. The palmitate was the superior ester and was bioequivalent to the hydrochloride in man.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 2 (1970), S. 453-454 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 7 (1973), S. 227-228 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 847-864 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A finite beam-column element computer program for the structural failure analysis of proportionally loaded skeletal plane frames is described. The program, which is based on an iterative stiffness approach, provides for non-linear elastic or plastic-non-linear elastic behaviour. Particular attention is given to the incorporation into the analysis of geometrical imperfections, return of elasticity at plastic hinges and negative frame stiffness. The effect of lack-of-fit displacements on the load-deflection path and failure load of frames that carry relatively large axial loads is described in general terms. The theory is developed further through the application of the computer program to two examples which show the necessity for the allowing for the effect of imperfections when designing axially loaded redundant frames.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 5 (1972), S. 65-82 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An alternative approach to the usual finite element treatment of steady-state temperature problems is presented, using approximations for the field of the dual variables.The appropriate extremum principle is established and its minimization is discussed in connection with a plane triangular finite element process. Original heat flow elements are derived: in conjunction with temperature elements, they enable dual analysis of a given structure and an important estimate of the convergence to the true solution by upper and lower bounds to the dissipation function, as illustrated by means of several examples.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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