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  • 1970-1974  (4)
  • Morphine  (2)
  • Chemistry  (1)
  • Compound eye  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Morphine dependence in rats with medial forebrain bundle lesions (1973)
    Springer
    Psychopharmacology 30 (1973), S. 343-348 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Withdrawal ; Addiction ; Dependence ; Medial Forebrain Bundle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats with posterior medial forebrain bundle (PMFB) lesions and control rats were administered morphine chronically for 4 or 5 days via implanted subcutaneous silicone reservoirs. Following cessation of morphine administration after five days, PMFB rats showed less withdrawal-induced weight loss than control rats. Other PMFB and control rats were subjected to forced drinking of morphine solution for 9 days. PMFB rats consumed the morphine solution much more readliy than control rats, whereas intake of a quinine solution was similar in two other PMFB and control groups. These results suggest that the addictive and dependence properties of morphine may have separate mechanisms and based on previously reported neurochemical effects of PMFB lesions, that biogenic amines may be differentially involved in such mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429193
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of morphine on sleep in the cat (1972)
    Springer
    Psychopharmacology 24 (1972), S. 435-448 
    Details
    ISSN: 1432-2072
    Keywords: Sleep ; Morphine ; Naloxone ; α-Methyltyrosine ; 5-Hydroxy-tryptophan.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of morphine sulfate, 300 μg/kg s.c., on the sleep of cats was studied by electroencephalographic techniques. In contrast to placebo experiments the animals were awake for approximately 6 h after administration of morphine; the return of regular sleep patterns occurred after about 11 h. A rebound increase in rapid eye movement (REM) sleep time and percentage was noted during the 11th through the 17th hour of the study. Sleep following manual sleep deprivation for 10 h showed a rebound increase in REM and non-rapid eye movement (NREM) sleep time. NREM sleep rebound after manual sleep deprivation exceeded that occurring after morphine. The alerting actions of morphine could be blocked by naloxone, 100 μg/kg s.c., for about 90 min. Naloxone alone increased REM sleep time and percentage. Single (84 mg/kg) or multiple (51 mg/kg for 4 injections) doses of dl-α-methyltyrosine i.p. did not block the alerting action or REM sleep rebound caused by morphine. 5-Hydrotryptophan (30 mg/kg) i.p. did not antagonize the alerting action of morphine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402538
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Surface fine structure of the eye of the housefly (Musca domestica): Ommatidia and lamina ganglionaris (1974)
    Springer
    Cell & tissue research 149 (1974), S. 21-41 
    Details
    ISSN: 1432-0878
    Keywords: Compound eye ; Musca domestica ; Ommatidia ; Optic cartridge ; Basement membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The compound eye of the housefly, from lens to first optic neuropile (lamina ganglionaris) was examined with a scanning electron microscope. Key findings are as follows: The pseudocone cavity is enclosed by six corneal pigment cells. The nuclei of the six cells are firmly anchored to the underside of the lens and portions remain after lens delamination from the pseudocone cavity. An eccentrically-positioned, short photoreceptor cell was observed near the region where the inferior central cell initiates its rhabdom. This eminence may represent that cell's soma. The basement membrane is revealed as a two-tiered, fibrous layer with ovoid fenestrations. Each opening is sealed with a diaphragm perforated by eight retinular axons and a trachea. Conjoined distal surfaces of the satellite glial cells form a membrane-like barrier immediately underlying the basement membrane. Monopolar somata from the lamina are covered with glial cells which possibly make more intimate contact with the somata through miniscule projections. Optic cartridges with monopolar interneurons were noted. Spherical to slightly biconcave processes of these interneurons contact retinular axons. Very fine (1000 Å) filaments interweave among and contact lateral processes. Further implications are discussed as they relate to observed structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209048
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of non-complementary nucleotides on the rate of helix formation: Kinetics of formation of poly (I)·poly (C,I) and poly (I)·poly (C,U) complexes (1972)
    New York : Wiley-Blackwell
    Biopolymers 11 (1972), S. 1613-1620 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Apparent second-order rate constants for complex formation between poly (I) and poly (C) and copolymers of C containing non-complementary I or U residues have been determined spectrophotometrically. The rate constants decrease as the concentration of either I or U in the C strands increases-the effect seems insensitive to the species of residue involved, when differences in the thermal stabilities of the poly (I) poly (C,I) and poly (I). poly (C,U) complexes are taken into account. These results suggest that low concentrations of relatively stable defects can alter the apparent kinetic “complexity” of polynucleotides as determined by hybridization methods (C0t analysis).
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1972.360110808
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    Paper (German National Licenses)
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