Electronic Resource
Springer
Naunyn-Schmiedeberg's archives of pharmacology
272 (1972), S. 369-377
ISSN:
1432-1912
Keywords:
Trimethoprim
;
Placental Transfer
;
Distribution
;
Elimination
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary After a single i.v. administration of 50 mg/kg of Trimethoprim (TM) to rats in late pregnancy, a diffusion equilibrium of the folic acid inhibitor in the foetal organs is reached after 30–60 min. The TM levels in maternal as well as in foetal organs can have an inhibitory effect on folic acid reductase activity. The elimination of TM is lower in pregnant than in non-pregnant animals. The TM elimination of the foeti is dependent on the elimination capacity of the mother. Three-days-old rats eliminate TM some four times slower than mature animals owing to their reduced kidney development.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00501243
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