ISSN:
1432-2072
Schlagwort(e):
Ethanol
;
Operant Performance
;
Dose-Response Analysis
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract The effects of various doses of ethanol on DRL performance was examined in rats under conditions of cued and non-cued DRL tasks and under conditions of low versus high baseline performance criteria. The dose-level at which ethanol produced a significant reduction in number of responses and reinforcements interacted in a complex fashion with level of baseline performance, the cue conditions, and the order of DRL tasks. Generally, performance was impaired at a lower dose level for groups initially trained to a low criterion of DRL performance than for groups later trained to a higher criterion of DRL performance, regardless of cue condition. Further, the dose level at which ethanol impaired performance (as indicated by number of reinforcements obtained) under non-cued DRL conditions was lower than that for the cued DRL conditions, but only on the initial task where baseline DRL performance criterion was lower. Finally, the group with a higher baseline level of responding (i.e., poorer DRL performance) was more vulnerable to the disrupting effects of ethanol on this measure than groups with lower baseline response rates.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00422755
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