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Digitale Medien

Nicotine as a discriminative cue in rats: Inability of related drugs to produce a nicotine-like cueing effect (1972)

Schechter, Martin D. ; Rosecrans, John A.

Springer

Psychopharmacology 27 (1972), S. 379-387

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Details

ISSN: 1432-2072

Schlagwort(e): Nicotine ; State-Dependent Behavior ; Lobeline ; Amphetamine ; Arecoline

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Rats were trained to enter one arm of a T-maze after the subcutaneous administration of 0.4 mg/kg and to enter the opposite arm following the injection of an equal volume of saline. Administration of 0.4 mg/kg nicotine isomethonium iodide hydroiodide, 0.4–10.0 mg/kg lobeline sulfate, 2.0 and 4.0 mg/kg d-amphetamine sulfate and 0.25–2.0 mg/kg arecoline hydrobromide produced responses which resembled the established saline effect. Pretreatment with 10.0 mg/kg lobeline had no significant effect on the nicotine-cued response. The inability of these structurally and/or functionally similar drugs to produce a nicotine-like discriminative effect is discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00429392

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