ISSN:
1432-2072
Keywords:
Nicotine
;
State-Dependent Behavior
;
Lobeline
;
Amphetamine
;
Arecoline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Rats were trained to enter one arm of a T-maze after the subcutaneous administration of 0.4 mg/kg and to enter the opposite arm following the injection of an equal volume of saline. Administration of 0.4 mg/kg nicotine isomethonium iodide hydroiodide, 0.4–10.0 mg/kg lobeline sulfate, 2.0 and 4.0 mg/kg d-amphetamine sulfate and 0.25–2.0 mg/kg arecoline hydrobromide produced responses which resembled the established saline effect. Pretreatment with 10.0 mg/kg lobeline had no significant effect on the nicotine-cued response. The inability of these structurally and/or functionally similar drugs to produce a nicotine-like discriminative effect is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429392
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