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Digitale Medien

A study of the influence of pH on the buccal absorption and renal excretion of procainamide (1974)

Meyer, W. ; Kaye, C. M. ; Turner, P.

Springer

European journal of clinical pharmacology 7 (1974), S. 287-289

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Details

ISSN: 1432-1041

Schlagwort(e): Procainamide ; buccal absorption ; renal excretion ; urine ; pH

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The buccal absorption of procainamide was studied in 4 normal, male volunteers over a pH range of 5–11. In another investigation the same 4 volunteers collected their urine for 24 h after taking 250 mg of procainamide hydrochloride orally on 3 separate occasions, during which urine pH was uncontrolled, acidified by ammonium chloride ingestion or alkalinised by sodium bicarbonate ingestion. The procainamide remaining after buccal absorption and present in the urine samples was determined spectrophotometrically. It was found that neither the buccal absorption nor the renal excretion of procainamide was substantially altered by changes in pH.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00560346

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