ISSN:
1432-1041
Keywords:
Pharmacokinetics
;
retard formulations
;
retard quotients
;
sustained release
;
half-value duration
;
dibenzepin hydrochloride
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In vivo criteria are proposed for the assessment of retard formulations. If the pharmacokinetics of the retard formulation tested and of the normal preparation are known, in either plasma or urine, two retard quotients can be defined which define the sustained release. One of the quotients refers to the width (half-value duration) and the other to the height of the plasma concentration time curve of the retard form as compared to the conventional preparation. From these criteria it is possible to draw useful conclusions about thein vivo quality of a retard formulation in an early stage of development of the dosage form. As a practical example the criteria have been applied to Noveril® 240 tablets (dibenzepin hydrochloride), the retard effect of which has made it possible to reduce the frequency of administration from three times daily to once a day.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00560355
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