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  • 1970-1974  (3)
  • 1
    Electronic Resource
    Electronic Resource
    The relation between cell division rate and 3HTdR incorporation in organ culture (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 81 (1973), S. 171-180 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Rates of incorporation of labelled thymidine (RIT), radioautographic labelling index for DNA synthesis (LI) and mitotic incidence following colcemid metaphase arrest (MI) were measured in organ cultures of newborn and adult rat lung. In adult cultures these three parameters correlated well, being low after explantation and reaching a maximum after two to three days. In newborn cultures RIT fell several fold over the first 24 hours after explantation and, in this respect, did not correlate with LI and MI. The changes in RIT over the first 24 hours appear to be due to changes in the degree of competition between endogenous TdR and exogenous labelled TdR, probably caused by leakage of the intracellular thymidine pool following explantation. The report emphasizes the need to check RIT data against radioautographic evidence before accepting it as an index of DNA synthesis.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040810206
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Stimulation of cell division following unilateral collapse of the lung (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 180 (1974), S. 681-686 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Collapse of the left lung in adult mice is followed by an increased mitotic incidence (MI) in the right lung which persists for approximately four days after operation. This compensatory increase in MI does not occur if the left thoracic cavity is packed with an implant of cotton wool which prevents hyperinflation of the right lung. The rate of incorporation of labelled thymidine per unit of DNA (RIT) is higher in the right than in the left lung of unoperated animals but after collapse of the left lung there is a reduction in the ratio of right to left in respect of RIT. These differences in RIT do not appear to correspond to changes in the rate at which cells enter DNA synthesis and it is suggested that they are due to differences in vascularisation between the right and left lungs. The compensatory increase in MI which follows unilateral collapse is not due to loss of tissue mass, to tissue damage or to the direct effects of the increased physiological load placed upon the remaining functional tissue. It is suggested that hyperinflation of the right lung causes changes in the rate of blood flow through that part of the organ and that, in consequence, there is a change in the local concentration of metabolites including those whose function is to regulate the mitotic rate.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091800412
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Morphogenetic and proliferative changes in the regenerating lung of the rat (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 176 (1973), S. 389-395 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Unilateral extirpation of the lung in rats is followed by increased mitotic activity in alveolar cells of the contralateral lung, reaching a maximum six to seven days after operation. The response is delayed if the cavity created by the operation is packed with plastic sponge. Unilateral collapse of the lung without removal of tissue also leads to a contralateral mitotic response. Changes in the rate of cell proliferation evidently are not directly dependent on changes in tissue mass and it is suggested that compensatory growth in the lung may be controlled by chemical factors whose local concentration depends on variations in the rate of blood flow.Other changes which follow partial extirpation, observed particularly in the residual tissue of resected lungs, include high rates of proliferation in pleural cells, sub-pleural tissue and bronchial epithelium. It appears that in the regenerating lung new tissue may be formed partly by the proliferation of cells in the main mass of residual tissue and partly by more localized changes in specific tissues.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091760403
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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