ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Collapse of the left lung in adult mice is followed by an increased mitotic incidence (MI) in the right lung which persists for approximately four days after operation. This compensatory increase in MI does not occur if the left thoracic cavity is packed with an implant of cotton wool which prevents hyperinflation of the right lung. The rate of incorporation of labelled thymidine per unit of DNA (RIT) is higher in the right than in the left lung of unoperated animals but after collapse of the left lung there is a reduction in the ratio of right to left in respect of RIT. These differences in RIT do not appear to correspond to changes in the rate at which cells enter DNA synthesis and it is suggested that they are due to differences in vascularisation between the right and left lungs. The compensatory increase in MI which follows unilateral collapse is not due to loss of tissue mass, to tissue damage or to the direct effects of the increased physiological load placed upon the remaining functional tissue. It is suggested that hyperinflation of the right lung causes changes in the rate of blood flow through that part of the organ and that, in consequence, there is a change in the local concentration of metabolites including those whose function is to regulate the mitotic rate.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091800412
