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  • 1965-1969  (7)
  • 1960-1964  (1)
  • 1950-1954  (1)
  • 1890-1899  (1)
  • 1880-1889  (2)
  • 1870-1879  (1)
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 26 (1954), S. 586-587 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 20 (1969), S. 29-40 
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 195 (1962), S. 1046-1048 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ONE of the most common features of bedded or foliated rocks seen in the field is the folding of surfaces which are presumed to have been initially plane. This folding may have arisen in a number of ways, depending on the circumstances, and it hasbeen the subject of many theoretical and experimental ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 8 (1897), S. 191-248 
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Probability theory and related fields 14 (1969), S. 161-168 
    ISSN: 1432-2064
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary X 1,⋯,X〉 n are independent, identically distributed random variables with common density function f(x¦θ 1 ,⋯,θ k ,θ k+1 ), assumed to satisfy certain standard regularity conditions. The k+1 parameters are unknown, and the problem is to test the hypothesis that θ k+1 =b against the alternative that θ k+1 =b+cn −1/2 . θ 1 ,⋯,θ k are nuisance parameters. For this problem, the following artificial problem is temporarily substituted. It is known that ¦θ 1 -a i ¦≦n −1/2 M(n) for i=1,⋯,k, where a 1 , ⋯,a k are known, and M(n) approaches infinity as n increases but n −1/2 M(n) approaches zero as n increases. A Bayes decision rule is constructed for this artificial problem, relative to the a priori distribution which assigns weight A to θ k+1 =b, and weight 1-A to θ k+1 =b+cn −1/2 , in each case the weight being spread uniformly over the possible values of θ 1 ,⋯,θ k in the artificial problem. An analysis of the structure of the Bayes rule shows that if estimates of θ 1 ,...,θ k are substituted for a 1 ..., a k respectively, the resulting rule is a solution to the original problem, and this rule has the same asymptotic properties as a solution to the artificial problem as the Bayes rule for the artificial problem, no matter what the values a 1 ..., a k are.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Schlüsselenzyme Acetyl-CoA-Carboxylase (geschwindigkeitsbegrenzender Schritt der Fettsäuresynthese), Citrat-synthase (einleitender Schritt des Citronensäurecyclus) und Glucose-6-phosphatdehydrogenase (erster Schritt des Hexosemonophosphatabbaues) werden in vitro hochempfindlich durch die Coenzym A-Thioester langkettiger Fettsäuren — vor allem Stearyl-CoA und Palmityl-CoA — gehemmt. Die wirksamen Konzentrationen dieser Verbindungen liegen in gleicher Größenordnung wie diejenigen, die man in der Leber antrifft. Auf Grund der kinetischen Daten kann man vermuten, daß die Coenzym A-Thioester nicht unmittelbar an den katalytischen Enzymzentren angreifen, sondern daß die Hemmung mittelbar (cooperativ) durch (allosterische) Änderungen der Proteinstruktur ausgelöst wird. Die Stellung der betroffenen Enzyme im Stoffwechsel sowie die Ergebnisse ausführlicher in vivo-Untersuchungen machen es wahrscheinlich, daß die langkettigen Fettsäure-Thioester des Coenzym A als körpereigene Wirkstoffe (Kontroll-Metabolite) in die Regulation folgender Stoffwechselabschnitte eingeschaltet sind: a) Die cytoplasmatische Biosynthese langkettiger Fettsäuren aus Acetyl-Coenzym A. b) Die Endoxydation des Acetyl-CoA über den Citronensäurecyclus. c) Den direkten Glucoseabbau über den Hexosemonophosphatweg. Einige pathophysiologische Merkmale des Leberstoffwechsels des akut-dekompensierten Diabetes mellitus und verwandter Zustände — nämlich Hemmung der Lipoidsynthese, gesteigerte Ketonkörperbildung und Unterdrückung des direkten Glucoseabbaues — könnten auf diese Weise unter einem gemeinsamen Nenner erklärt werden.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Probability theory and related fields 7 (1967), S. 327-335 
    ISSN: 1432-2064
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 14 (1875), S. 203-203 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 68 (1966), S. 345-359 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: An attempt has been made to locate RNA as a structural component of the peripheries of cultured cells derived from a human osteogenic sarcoma, and L1210 mouse leukaemia cells. In the case of cells derived from the osteogenic sarcoma, their detachment from glass was facilitated by incubation with ribonuclease; on removal from glass, they left cellular “footprints” behind, which were visulized in radioautographs of cells previously labeled with tritiated uridine, and removable with ribonuclease. The electrophoretic data show loss of charge by both types of cell following incubation with ribonuclease.These results are interpreted to indicate that RNA is a structural component of the peripheries of these cells. No attempt is made to speculate on the obvious biological improtance of these observations if they are applicable to cells in general.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: RNA in the peripheries of various populations of lymph node cells (LNC) has been evaluated by measuring the electrophoretic mobilities of cells, before and after treatment with active or inactivated ribonucleases. Three different populations of LNC were studied: (1) “resting” normal age control LNC; (2) “syngeneic” LNC from irradiated (C3H × C57BL)F1 or C3H mice four to six days following transplantation of syngeneic spleen cells; such cells were progeny of lymphopoietic progenitor cells of the spleen; and (3) “allogeneic” LNC from irradiated (C3H × C57BL)F1 mice four to six days after grafting C3H (parental) spleen cells; such cells were progeny of lymphopoietic progenitor cells, but also alloantigen-sensitive cells of the spleen which proliferate in response to the host's alloantigens (a “graft-versus-host” immunological reaction). Whereas the normal LNC had no detectable peripheral RNA, the allogeneic and syngeneic LNC did, i.e., ribonuclease reduced their mean electrophoretic mobilities by 13.6 and 9.2 per cent, respectively. Since both allogeneic and syngeneic LNC had peripheral RNA, no specific correlation could be made with immunological activity. 3H-uridine and 14C-thymidine incorporation into lymph nodes was greatest in allogeneic, intermediate in syngeneic and least in age control lymph nodes, indicating a “population shift” in the spleen cell chimeras toward relatively immature, rapidly proliferating cells, which had a relatively high rate of RNA synthesis. Thus, rapidly proliferating lymphoid cells do have RNA in their peripheries, but its relation to specific immunological function has yet to be ascertained.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
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