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  • 1
    Electronic Resource
    Electronic Resource
    A prospective trial of computed tomography in the staging of ovarian malignancy (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Thirty patients, thought clinically to have ovarian tumours, were studied prospectively by pre-operative computed tomographic (CT) scans of the abdomen and pelvis. In six patients (20%) small metastases in mesentery, omentum and on subdiaphragmatic peritoneum were not detected by the scans. CT did not improve the accuracy of staging or assist the surgeons by drawing their attention to disease which they might otherwise have missed. Although CT gives an elegant demonstration of anatomy, it is not an alternative to extended laparotomy in patients with ovarian tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb01116.x
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanisms of Synaptic Vesicle Recycling Illuminated by Fluorescent Dyes (1999)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 73 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract : The recycling of synaptic vesicles in nerve terminals involves multiple steps, underlies all aspects of synaptic transmission, and is a key to understanding the basis of synaptic plasticity. The development of styryl dyes as fluorescent molecules that label recycling synaptic vesicles has revolutionized the way in which synaptic vesicle recycling can be investigated, by allowing an examination of processes in neurons that have long been inaccessible. In this review, we evaluate the major aspects of synaptic vesicle recycling that have been revealed and advanced by studies with styryl dyes, focussing upon synaptic vesicle fusion, retrieval, and trafficking. The greatest impact of styryl dyes has been to allow the routine visualization of endocytosis in central nerve terminals for the first time. This has revealed the kinetics of endocytosis, its underlying sequential steps, and its regulation by Ca2+. In studies of exocytosis, styryl dyes have helped distinguish between different modes of vesicle fusion, provided direct support for the quantal nature of exocytosis and endocytosis, and revealed how the probability of exocytosis varies enormously from one nerve terminal to another. Synaptic vesicle labelling with styryl dyes has helped our understanding of vesicle trafficking by allowing better understanding of different synaptic vesicle pools within the nerve terminal, vesicle intermixing, and vesicle clustering at release sites. Finally, the dyes are now being used in innovative ways to reveal further insights into synaptic plasticity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0732227.x
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical evaluation of the effect of a proteolytic enzyme mouthwash on plaque and gingivitis in young adults (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Community dentistry and oral epidemiology 3 (1975), S. 0 
    Details
    ISSN: 1600-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: One hundred and thirty-one young adults were used in a controlled study to determine whether a proteolytic mouthwash produced from B. subtilis could help remove existing plaque, decrease the rate of plaque accumulation or reduce the clinical signs of gingivitis. These subjects were stratified by means of the Gingival Index and the Shaver-Schiff Plaque Index into severe or mild groups. These groups were further divided in a random fashion into treatment and placebo groups. The treatment group rinsed with a proteolytic mouthwash consisting mainly of neutral and alkaline proteases and amylase. A placebo mouthwash was used by the control group. The results of this investigation indicate that there is no statistically significant reduction either in existing plaque or in the rate of plaque accumulation when this proteolytic enzyme mouthwash is used. Furthermore, in the treatment group the degree of gingivitis as measured by the GI was not reduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0528.1975.tb00323.x
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  • 4
    Electronic Resource
    Electronic Resource
    Transamidase and collagenase activity in healthy and diseased human gingival tissues (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 21 (1992), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Transamidases are a class of calcium–dependent mammalian enzymes which crosslink proteins by catalyzing the formation of (γ–glutamyl)–ε–lysine bonds. It is possible that these enzymes play an important anabolic role in tissue healing. This study was to quantitate transamidase activity in human gingival tissue and examine the relation between transamidase activity and degree of inflammation. Forty–four out of a total 120 collected human gingival specimens from healthy and diseased patients were selected based on histometric and microbiologic criteria. Specimens were minced and homogenized in 10 mM CaCl2 and then extracted for 30 min, in 50 mM tris–HCl buffer (pH 7.5) containing 100 mM CaCl2. Following low speed centrifugation at 4 C, the supernatant solution was assayed for both transamidase and collagenase activities by radioactive amine incorporation, and digestion of tritiated collagen, respectively. Appreciable levels of transamidase and collagenase activities in healthy gingivae were found. These enzyme activities were significantly elevated in the diseased and healing tissues. Unlike other transamidases, calcium was required in the enzyme extraction process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1992.tb00977.x
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  • 5
    Electronic Resource
    Electronic Resource
    Activation of human gingival collagenase (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To study the regulation of collagen degradation in periodontium, human gingival homogenate was incubated at 36°C and the release of hydroxyproline was assayed as a measure of collagenase activity. Phenylmethylsulfonyl fluoride, soybean trypsin inhibitor and scrum albumin inhibited the in vitro collagenolysis while p-aminophenylmcreuric acetate, a sulfhydryl reagent, increased the degradation. When latent collagenase obtained from gingival fibroblast culture was added to the incubation a marked increase in the collagen degradation was found. This increase was prevented by phenylmethylsulfonyl fluoride. The data suggests that collagenase may exist in gingiva partly in a latent form and its activation may be brought about by 2 mechanisms. A serine proteinase present in tissue may activate collagenase by producing a limited clevage, or the activation may occur through a reaction that involves the sulfhydryl groups of the collagenase molecule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01441.x
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  • 6
    Electronic Resource
    Electronic Resource
    A short term evaluation of periodontal surgery (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 14 (1979), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1979.tb00790.x
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  • 7
    Electronic Resource
    Electronic Resource
    Development of a force controlled periodontal probing instrument (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 14 (1979), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1979.tb00222.x
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  • 8
    Electronic Resource
    Electronic Resource
    The effect of endotoxin and human dental plaque on the respiratory rate of bone cells (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 10 (1975), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of endotoxin and heat treat dental plaque on the respiratory activity of intact, viable bone cells was studied. cells were isolated from the zone of provisional calcification of chick epiphyseal plates. The mean rate of oxygen consumption was 20.7 × 10−9 per atom/min/cell. This was reduced by 36% in the presence of 0.1% endotoxin and by 16.1% when exposed to 0.1% heat treated dental plaque. The results suggest that endotoxin mediates bone resorption through stimulation of anaerobic metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1975.tb00038.x
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  • 9
    Electronic Resource
    Electronic Resource
    The relationship between gingival inflammation and resistance to probe penetration (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 14 (1979), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The present investigation was carried out to determine the location of the periodontal probe tip when various loads are applied. Additionally, the role of gingival inflammation to probe resistance was evaluated.The sample consisted of 51 teeth scheduled for extraction. The Gingival Index (GI) was used to establish the degree of inflammation. A loading of 20,25,30 ponds was delivered by a spring loaded sleeve bearing probe fitted with a michigan 0 probe having a terminal diameter of 0.35 mm. The extracted teeth were fixed and then stained with 4% toluidine blue. Using a coronal reference groove and the apical margin of the connective tissue attachment (CTA) as reference points apical penetrtion of the probe was established.The results of this study indicate that there is a linear relationship between the GI and the resistance of the gingival tissues to probe penetration. This is most apparent between a GI = 0 amd GI = 3. Wjereas with 30 ponds the mean penetration at GI = 0 was 0.30 mm. coronal to the CTA, the mean penetration was 1.25 mm apical to the CTA at GI = 3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1979.tb00229.x
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  • 10
    Electronic Resource
    Electronic Resource
    CAPILLARY PERMEABILITY OF HETEROGENEOUS ORGANS: A PARSIMONIOUS INTERPRETATION OF INDICATOR DIFFUSION DATA (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Calculations of capillary permeability of perfused organs from indicator diffusion data are reviewed, and reconsidered in terms of two kinds of organ heterogeneity of capillary extraction.3. In the presence of realistic back-diffusion and recirculation of the indicator, the foregoing expression for PS is converted into a secure lower bound of the organ PS. Using data from four previously published studies of the brain and of the heart as examples, it is shown that this lower bound approaches and sometimes exceeds the widely differing PS values estimated by four existing methods based on more restrictive assumptions. In particular, PS estimates from the initial extraction (Eo method) fall below the lower bound in three of the four cases.4.The new results are valid without restriction on the magnitudes of the extraction fractions, so that they provide legitimate PS estimates even for highly diffusible indicators.5. Quantitative hypotheses needed for more complete modelling of indicator diffusion are reviewed, and elaborated in terms of both deterministic and probabilistic models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1982.tb00820.x
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