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  • 1
    Electronic Resource
    Electronic Resource
    A prospective trial of computed tomography in the staging of ovarian malignancy (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Thirty patients, thought clinically to have ovarian tumours, were studied prospectively by pre-operative computed tomographic (CT) scans of the abdomen and pelvis. In six patients (20%) small metastases in mesentery, omentum and on subdiaphragmatic peritoneum were not detected by the scans. CT did not improve the accuracy of staging or assist the surgeons by drawing their attention to disease which they might otherwise have missed. Although CT gives an elegant demonstration of anatomy, it is not an alternative to extended laparotomy in patients with ovarian tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb01116.x
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanisms of Synaptic Vesicle Recycling Illuminated by Fluorescent Dyes (1999)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 73 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract : The recycling of synaptic vesicles in nerve terminals involves multiple steps, underlies all aspects of synaptic transmission, and is a key to understanding the basis of synaptic plasticity. The development of styryl dyes as fluorescent molecules that label recycling synaptic vesicles has revolutionized the way in which synaptic vesicle recycling can be investigated, by allowing an examination of processes in neurons that have long been inaccessible. In this review, we evaluate the major aspects of synaptic vesicle recycling that have been revealed and advanced by studies with styryl dyes, focussing upon synaptic vesicle fusion, retrieval, and trafficking. The greatest impact of styryl dyes has been to allow the routine visualization of endocytosis in central nerve terminals for the first time. This has revealed the kinetics of endocytosis, its underlying sequential steps, and its regulation by Ca2+. In studies of exocytosis, styryl dyes have helped distinguish between different modes of vesicle fusion, provided direct support for the quantal nature of exocytosis and endocytosis, and revealed how the probability of exocytosis varies enormously from one nerve terminal to another. Synaptic vesicle labelling with styryl dyes has helped our understanding of vesicle trafficking by allowing better understanding of different synaptic vesicle pools within the nerve terminal, vesicle intermixing, and vesicle clustering at release sites. Finally, the dyes are now being used in innovative ways to reveal further insights into synaptic plasticity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0732227.x
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  • 3
    Electronic Resource
    Electronic Resource
    Physical properties of periodontal dressing materials (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 13 (1986), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to develop standardized reproducible testing methods for evaluating physical properties of periodontal dressing materials. Three commercial compositions (Coe-Pak, Coe-Pak Hard & Fast Set and WondrPak) were studied.Working and setting times were determined by observing the continuous changes in viscosity via the oscillating rheometer. The 24-h and 1-week tensile and shear adhesive bonds to enamel were studied by luting orthodontic lingual cleats with a standard film thickness to the orientated labial surfaces of extracted incisors and pulling them to failure. Dimensional change was studied over a period of 24h using a linear variable differential transformer (LVDT).The developed testing modalities have greater precision than those previously reported. The concept of ‘bench time’ was developed during which certain materials cannot be handled immediately after mixing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1986.tb00681.x
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  • 4
    Electronic Resource
    Electronic Resource
    CAPILLARY PERMEABILITY OF HETEROGENEOUS ORGANS: A PARSIMONIOUS INTERPRETATION OF INDICATOR DIFFUSION DATA (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Calculations of capillary permeability of perfused organs from indicator diffusion data are reviewed, and reconsidered in terms of two kinds of organ heterogeneity of capillary extraction.3. In the presence of realistic back-diffusion and recirculation of the indicator, the foregoing expression for PS is converted into a secure lower bound of the organ PS. Using data from four previously published studies of the brain and of the heart as examples, it is shown that this lower bound approaches and sometimes exceeds the widely differing PS values estimated by four existing methods based on more restrictive assumptions. In particular, PS estimates from the initial extraction (Eo method) fall below the lower bound in three of the four cases.4.The new results are valid without restriction on the magnitudes of the extraction fractions, so that they provide legitimate PS estimates even for highly diffusible indicators.5. Quantitative hypotheses needed for more complete modelling of indicator diffusion are reviewed, and elaborated in terms of both deterministic and probabilistic models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1982.tb00820.x
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  • 5
    Electronic Resource
    Electronic Resource
    MEASUREMENT OF BLOOD-BRAIN BARRIER PERMEABILITY (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 17 (1990), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Experimental determinations of blood-brain barrier permeability from measurements of uptake of tracers by brain are limited in two ways. First, there are experimental limitations that are specific to the particular method being used. These limitations include the range of permeability values that a particular method can reliably determine (sensitivity); whether repeated experiments are possible in the same animal; whether regional values can be determined; and to what degree the chemical composition of the perfusate passing through the brain can be controlled.2. A second set of limitations on permeability determinations is of a more general, physiological nature. These constraints apply to a greater or lesser degree to all experimental determinations, and may limit the accuracy and reliability of the permeability values obtained; although certain reliable upper and lower bounds can be determined. These general factors include: capillary heterogeneity (i.e. variations in capillary lengths, surface areas, blood flows, etc.); the possibility of binding to circulating plasma proteins, especially albumin; and the possibility of capillary recruitment and de-recruitment with changes in cerebral blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1990.tb01286.x
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  • 6
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    An Experiment in Probability Estimation (1965)
    Chicago : Periodicals Archive Online (PAO)
    Journal of marketing research. 2:3 (1965:Aug.) 266 
    Details
    ISSN: 0022-2437
    Topics: Economics
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:b178-1965-002-03-000006
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  • 7
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    Canonical Analysis: An Exposition and Illustrative Application (1966)
    Chicago : Periodicals Archive Online (PAO)
    Journal of marketing research. 3:1 (1966:Feb.) 32 
    Details
    ISSN: 0022-2437
    Topics: Economics
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:b178-1966-003-01-000003
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  • 8
    Electronic Resource
    Electronic Resource
    Correlation of histometric, microbial, and clinical indicators of periodontal disease status before and after root planing (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 14 (1987), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Effective diagnosis and treatment of periodontal disease requires accurate evaluation of disease status before and after treatment. This study evaluated relationships among multiple parameters that have been used for periodontal disease evaluation. A total of 61 initially deep (≥6 mm) interproximal pockets from 16 patients examined before and after a 3-week course of root planing therapy were evaluated for probing depth, bleeding on probing, darkfield and cultural characterization of subgingival plaque, and histometric indices of infiltrated connective tissue (ICT) and mature plasma cell infiltrate. 36 sites were evaluated before treatment, and 25 after treatment. A comparison of mean scores for pre-treatment sites versus post-treatment sites indicated that there was an average improvement in most disease-related parameters. However, patterns of significant correlations among the parameters differed markedly. Motile bacteria enumerated by darkfield microscopy were significantly correlated with ICT and plasma-cell populations before, but not after treatment. In contrast, probing depth and populations of black pigmented Bacteroides (BPB's). principally B. gingivalis, were significantly correlated with ICT after, but not before, treatment. Bleeding on probing was not significantly correlated with ICT levels before or after treatment. This suggests that different sets of parameters should be used for evaluating periodontal disease status before or after treatment. Our data further suggest that B. gingivalis populations may be related to delayed healing of deep periodontal lesions after instrumentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1987.tb00966.x
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  • 9
    Electronic Resource
    Electronic Resource
    MOLECULAR COMPLEXITY OF Qa-2 ANTIGENS DEMONSTRATED BY TWO-DIMENSIONAL GEL ELECTROPHORESIS (1987)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 14 (1987), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Biosynthetically labelled Qa-2 antigens were isolated from mouse spleen cells by immunoprecipitation with anti-Qa-2 antisera. When newly synthesized Qa-2 molecules from several different inbred strains were analysed by two-dimensional (2D) gel electrophoresis; four different phenotypes were observed that differed in the number of polypeptides present. The ability to distinguish Qa-2+ phenotypes was used to map the recombination points in two congenic strains, B6. Tlaa and A. Tlab. No alternative Qa-2-like polypeptides were detected in B6.K1 (Qa-2−) cells using a polyspecific rabbit antiserum against mouse class I antigens, but a new molecule was detected in BALB/cBy (Qa-2−) cells. Pulse-chase and surface-labelling experiments showed that some, but not all, of the newly synthesized Qa-2 precursor forms are processed to mature cell surface molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1987.tb00366.x
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  • 10
    Electronic Resource
    Electronic Resource
    Clinical evaluation of the effect of a proteolytic enzyme mouthwash on plaque and gingivitis in young adults (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Community dentistry and oral epidemiology 3 (1975), S. 0 
    Details
    ISSN: 1600-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: One hundred and thirty-one young adults were used in a controlled study to determine whether a proteolytic mouthwash produced from B. subtilis could help remove existing plaque, decrease the rate of plaque accumulation or reduce the clinical signs of gingivitis. These subjects were stratified by means of the Gingival Index and the Shaver-Schiff Plaque Index into severe or mild groups. These groups were further divided in a random fashion into treatment and placebo groups. The treatment group rinsed with a proteolytic mouthwash consisting mainly of neutral and alkaline proteases and amylase. A placebo mouthwash was used by the control group. The results of this investigation indicate that there is no statistically significant reduction either in existing plaque or in the rate of plaque accumulation when this proteolytic enzyme mouthwash is used. Furthermore, in the treatment group the degree of gingivitis as measured by the GI was not reduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0528.1975.tb00323.x
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