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  • 1965-1969  (5)
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  • 1
    Digitale Medien
    Digitale Medien
    The fine structure of intercellular substances and rounded cells in the incisor pulp of the guinea pigThis investigation was supported in part by a grant from the United States Public Health Service (D-1620) (1965)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 151 (1965), S. 41-57 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The fine structure of intercellular substances and rounded cells of the incisor dental pulp of guinea pigs is described. The extracellular fibrils are of two kinds; collagen with typical cross-striations, varying from 400-700 Å in diameter, and fine fibrils of 100-120 Å in diameter. In cross section the latter fibrils appeared to be composed of three or four smaller subunits of less than 50 Å in diameter. The collagen fibril in the dental pulp appear singly or in small bundles of about a dozen or more fibrils. The fine fibrils are often aggregated along the cell surface.The ground substances are finely granular to fibrillar and show localized clumping which is related to fibrillar elements. The ground substances form an incomplete covering of 200 Å or more in thickness surrounuding collagen fibrils. When the collagen fibrils make a bundle, the sheath of grouund substances around one fibril becomes fused with that of adjacent fibrils.Rounded cells including macrophages, lymphocytes and eosinophils are present in the pulp. The fine structure of these cells is similar to that found in the same types of cells previously observed in other organs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091510105
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  • 2
    Digitale Medien
    Digitale Medien
    The fine structure of differentiating fibroblasts in the incisor pulp of the guinea pigSupported in part by grant D-1620 from The United States Public Health Service. (1965)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 153 (1965), S. 187-209 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The differentiation of the fibroblast was followed in the dental pulp of continuously growing incisors of the guinea pig. Based on the ultrastructure, the processes of differentiation of the fibroblasts might be conveniently broken into three stages; Stage I - period of early differentiation, Stage II - period of maturation and functioning, and Stage III - period of regression.During Stage I the cell had structural characteristics shared by other less differentiated cells. The endoplasmic reticulum was poorly developed, showing vesicular to tubular profiles. The ribosomes were abundant but were mostly distributed in free form. Mitochondria were small and had irregular interiors.Stage II was characterized by a striking development of the rough-surfaced endoplasmic reticulum, which appeared in various shapes and sizes. The Golgi complex was enlarged, and contained some fibriller materials in dilated portions of its membraneous elements. Other features described in the cytoplasm of fibroblasts from other sources were confirmed.Stage III was characterized by the decrease in size and number of various cytoplasmic constituents and was considered to represent cells in the state of regression.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091530208
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  • 3
    Digitale Medien
    Digitale Medien
    Studies on hypoxia V. Effects of anoxia on developing connective tissue cells in ratsSupported in part by Grants HD-03147, DE-02311 and DE-02731 from the National Institutes of Health, U.S. Public Health Service. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 531-541 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The effect of anoxia on protein synthesis of developing connective tissue cells was studied by radioautography. Neonatal rats were subjected to anoxia for 20 minutes and were immediately injected with 3 μc/gm body weight of leucine-H3intraperitoneally. They were sacrificed at different intervals after injection. Control animals were handled identically, except that atmospheric air was made available. The heads of the animals were prepared for radioautography in the standard manner. The number of grains was counted over individual fibrobalsts, osteoblasts and chondrocytes of histologically comparable regions, and the data were statistically evaluated.The number of grains per cell was significantly lower in experimental animals sacrificed at one hour after the anoxic treatment and leucine-H3administration. At this time, the average grain number per cell in the experimental animal was less than 50% of the control. The difference was about 20% by four hours and was negligible after 24 hours. The result is interpreted to indicate that the overall protein synthesis in connective tissues is immediately but temporarily suppressed by anoxia and that such suppression might lead to a later functional disturbance among these cells.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650408
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  • 4
    Digitale Medien
    Digitale Medien
    A study of salivary glands of rats injected with actinomycin DBased in part on a thesis for the degree of the Doctor of Medical Sciences in Anatomy, Yunsei University, Seoul.Supported by a grant from U.S.P.H.S. (D-1620-3). (1965)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 116 (1965), S. 631-651 
    Details
    ISSN: 0002-9106
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: A study has been made of the salivary glands of the rat following an injection of a sublethal dose of actinomycin D. Body weights and weights of the parotid and submandibular glands showed significant decreases during the first 7 to 14 days. The loss in weight was the greatest in the parotid gland.Histological and cytological observations indicated that the changes in secretory cells occurred in the following order: (1) beginning of nuclear pyknosis with a rapid decrease in number and size of nuclei by 24 hours after the injection; (2) advanced stages of nuclear pyknosis with concomitant decrease in cytoplasmic basophilia and granules by day 3; (3) apparent vacuolization and rarification of cytoplasm by day 7; (4) beginning of nucleolar and nuclear recovery by day 10; and (5) complete cytoplasmic recovery by the end of experiment as evidenced by the return of basophilia and disappearance of vacuoles.Paralleling the weight changes, cytological damages were greater in the parotid than in the submandibular acini. This was thought to be related to differences in nature of secretory products by the two organs. A decrease in number and pronounced irregularity in size of the granules in salivary ducts of the submandibular gland were observed but at a later time than the above mentioned changes in the acini. The significance of these changes has been discussed in light of the recently gained knowledge on the biosynthesis of nucleic acids and proteins as related to the chemical mechanism of actinomycin D in the inhibition of m-RNA synthesis.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aja.1001160308
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  • 5
    Digitale Medien
    Digitale Medien
    An electron microscopic and radioautographic study of the rat parotid gland after actinomycin D administrationThis study was supported in part by grants from U.S.P.H.S. (DE-1620) and from American Cancer Society (IN-40-F). (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 120 (1967), S. 161-183 
    Details
    ISSN: 0002-9106
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Rat parotid glands have been examined by electron microscopy and radioautography (H3-leucine incorporation) at various intervals following an injection of actinomycin D in the amount of 0.125 μg per gram of body weight. Light microscopic observations confirmed results from previous experiments similar to this. Radioautographs showed a definite drop in number of silver grains in acinar cells of the parotid from experimental animals. This was most pronounced in 7-day rats which received H3-leucine four hours prior to sacrifice. Electron microscopic observations revealed a generalized reduction in number and degree of the organization of organelles concerned with protein synthesis. Furthermore, frequent appearances of lipid droplets, cytolysomes and crystalloid structures were noted. Changes of the nucleolus included the reduction of its size and the formation of spherical encapsulated bodies. A brief discussion is made of these results in relation to the biochemical nature of actinomycin effects on protein producing cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aja.1001200113
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