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  • 1
    Electronic Resource
    Electronic Resource
    Enhanced in vivo sensitivity to interferon with in vitro resistant B16 tumor cells in mice (1994)
    Springer
    Cancer immunology immunotherapy 39 (1994), S. 148-154 
    Details
    ISSN: 1432-0851
    Keywords: Melanoma ; Antitumor response ; Interferon resistance ; rHuIFNαA/D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mouse B16 melanoma cells rapidly develop resistance to the antiproliferative effects of interferon α (IFNα) and interferon β (IFNβ) when they are exposed to the interferons in vitro. This resistance was characterized to be non-genetic and dose-dependent, and does not alter other IFN-induced effects such as antiviral effects and elevation of 2′,5′-oligoadenylate synthetase activity in IFN-treated cells. The study of these IFN-resistant cells has been extended to an in vivo tumor model. Resistance, if it occurred in vivo, did not adversely affect the survival of IFN-treated mice. Further, IFN-treated mice inoculated with B16 cells that were resistant in vitro (B16αres cells) survived significantly longer than IFN-treated mice inoculated with B16 cells that were sensitive in vitro. The IFN-treated B16αres-inoculated mice had a significantly higher cure rate as well. The prolonged survival of the mice bearing B16αres cell tumors did not seem to be caused by the slower growth rate of the B16αres cells, since experiments performed with a tenfold higher B16αres cell inoculum and a tenfold lower B16 cell inoculum did not show any change in the survival pattern. It is clear that in vitro resistant B16αres cells are more sensitive to antitumor effects induced by IFN in vivo than in vitro sensitive B16 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01533379
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation and distribution of a Drosophila protein preferentially associated with active regions of the genome (1989)
    Springer
    Chromosoma 97 (1989), S. 381-389 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A non-histone chromosomal protein of Mr = 75000 was isolated from Drosophila embryos. The distribution pattern of this protein was determined by indirect immunofluorescence on salivary gland chromosomes of Drosophila melanogaster third instar larvae and compared with the distribution pattern of RNA polymerase II. Despite its preferential association with transcriptionally active regions of the chromosomes there was in many cases an almost inverse correlation with the RNA polymerase II content of a given locus. We postulate a function of the Mr = 75000 protein in posttranscriptional regulation of gene expression by storing the newly synthesized RNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292765
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  • 3
    Electronic Resource
    Electronic Resource
    Enhanced in vivo sensitivity to interferon with in vitro resistant B16 tumor cells in mice (1994)
    Springer
    Cancer immunology immunotherapy 39 (1994), S. 148-154 
    Details
    ISSN: 1432-0851
    Keywords: Key words: Melanoma – Antitumor response – Interferon resistance – rHuIFNαA/D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Mouse B16 melanoma cells rapidly develop resistance to the antiproliferative effects of interferon α (IFNα) and interferon β (IFNβ) when they are exposed to the interferons in vitro. This resistance was characterized to be non-genetic and dose-dependent, and does not alter other IFN-induced effects such as antiviral effects and elevation of 2′,5′-oligoadenylate synthetase activity in IFN-treated cells. The study of these IFN-resistant cells has been extended to an in vivo tumor model. Resistance, if it occurred in vivo, did not adversely affect the survival of IFN-treated mice. Further, IFN-treated mice inoculated with B16 cells that were resistant in vitro (B16αres cells) survived significantly longer than IFN-treated mice inoculated with B16 cells that were sensitive in vitro. The IFN-treated B16αres-inoculated mice had a significantly higher cure rate as well. The prolonged survival of the mice bearing B16αres cell tumors did not seem to be caused by the slower growth rate of the B16αres cells, since experiments performed with a tenfold higher B16αres cell inoculum and a tenfold lower B16 cell inoculum did not show any change in the survival pattern. It is clear that in vitro resistant B16αres cells are more sensitive to antitumor effects induced by IFN in vivo than in vitro sensitive B16 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01533379
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis of pyrrolizidine alkaloids indicine, intermedine, lycopsamine, and analogs and their N-oxides. Potential antitumor agents (1985)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 28 (1985), S. 687-694 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00383a001
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis of congeners and prodrugs of the benzene maleimide photoadduct, mitindomide, as potential antitumor agents. 2 (1986)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 29 (1986), S. 2164-2170 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00161a006
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  • 6
    Electronic Resource
    Electronic Resource
    The Power Situation. (1951)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 43 (1951), S. 2662-2669 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50504a018
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  • 7
    Electronic Resource
    Electronic Resource
    Strained layer (111)B GaAs/InGaAs single quantum well lasers and the dependence of their characteristics upon indium composition (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 89 (2001), S. 4689-4696 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have studied a series of (111) oriented GaAs–InGaAs single quantum well, broad area lasers with active regions containing a range of indium concentrations, x, in order to understand the advantages and limitations of pseudomorphic strain. For x≤0.3, both an increased emission wavelength and reduced threshold current were observed with increasing x. The predominant cause of the wavelength increase is the reduction in bulk InGaAs band gap. The reduction in threshold current is attributed mainly to the reduced in-plane density of states caused by the strain induced lifting of the heavy and light hole degeneracy at the valence band edge. For x〉0.3, we see a marked deterioration in laser performance. However, we believe that this deterioration is not directly associated with strain relaxation at layer thicknesses beyond the critical value. Rather, imperfections in the AlGaAs cladding layers appear to seed the formation of dislocations within the strained regions. Within the limitation of strain relaxation, we observed monomode continuous wave emission at room temperature at wavelengths up to 1.072 μm and with threshold current densities as low as 74 A/cm2. The differential gain of 1.45×10−15 cm2 is around four times higher than measured on unstrained GaAs/AlGaAs single quantum well lasers. Like the reduction in threshold current density, this relatively high value is attributed to the strain induced reduction in the in-plane, heavy hole effective mass. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1359155
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  • 8
    Electronic Resource
    Electronic Resource
    Experimental studies of high-power microwave reflection, transmission, and absorption from a plasma-covered plane conducting boundary (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 6313-6318 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Experimental studies of the reflection, transmission, and absorption of high-power microwave pulses from a plasma-covered plane conducting boundary are presented. Under optimum conditions, backscattered rf power is attenuated by more than 30 dB over values measured in the absence of the plasma. Measurements of the radial and axial plasma density profiles and the neutral gas pressure near the plane conductor indicate that collisional absorption processes are not the primary source of the observed attenuation in the backscattered microwave signal, and that the plasma density exceeds the critical density over much of the volume nearest the conductor. The effects of a tenfold reduction in the microwave power density on the reflection and absorption characteristics of the system are also reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.348829
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  • 9
    Electronic Resource
    Electronic Resource
    Endohedral complexes: Atoms and ions inside the C60 cage (1991)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 94 (1991), S. 3730-3734 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The results of ab initio electronic structure calculations on the C60 cage and its endohedral ("inside-the-cage'') complexes with F−, Ne, Na+, Mg2+, and Al3+ are presented. Placing the ions at the center of the cage results in a net stabilization and screening of the charges. The ionic guests either decrease (F−) or increase (Na+, Mg2+, and Al3+ ) the cage radii. The complexes with the ions at the cage center are local maxima with respect to the displacement of the guests. The C60⋅Ne complex, which is destabilized by ca. 0.4 kcal/mol relative to the separated components, is an energy minimum. In the C60⋅Na+ complex, the energy minimum (which lies only 0.8 kcal/mol below the maximum) corresponds to the Na atom displaced by 0.66 A(ring) from the cage center. The calculated properties of the endohedral complexes are easily rationalized with a model involving a double-layer polarizable C60 cage affected by the electrostatic potential produced by the enclosed guests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.459744
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  • 10
    Electronic Resource
    Electronic Resource
    Numerical drift orbit calculations for force-free spheromak configurations (1990)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 2 (1990), S. 554-560 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A numerical analysis was performed of guiding-center (gc) orbits in a variety of spheromak-type force-free, numerically determined equilibria including the normal spherical configurations as well as configurations that are more prolate and oblate, and others having hollow or peaked current profiles. The calculated drift orbits differ significantly from the well-known drift orbits in tokamaks. In particular, the results indicate (i) the existence of particles trapped in separate hemispheres, (ii) the orbit widths d are about proportional to the Larmor radius ρ of the particle (calculated for the field maximum) up to ρ≈0.01–0.02 of the major separatrix dimension, (iii) many orbits, in particular on the outer flux lines, have their maximum normalized width dmax/ρL(ρL= local Larmor radius) away from the midplane of the configuration, and (iv) these maximum normalized widths are about 2–4 over most of the volume for all configurations except for prolate ones with a peaked current profile; in the latter configurations, orbits on outer field surfaces show dmax≤ρL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.859292
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