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Fusicoccane-, dolabellane- and rearranged labdane-type diterpenoids from the liverwort Pleurozia gigantea

Asakawa, Y. ; Lin, X. ; Tori, M. ; [et al.]

Amsterdam : Elsevier

Phytochemistry 29 (1990), S. 2597-2603

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ISSN: 0031-9422

Keywords: (-)-3,14-clerodadien-13-ol ; 14-labden-8,13-diol ; 18-hydroxy-4,8-dolabelladiene ; Hepaticae ; Jungermanniales ; Pleurozia gigantea ; ^1H detected multiple bond connectivity (HMBC) ; chemosystematics ; fusicoccane-, dolabel-lane-, rearranged labdane-, clerodane- and ; fusicogigantepoxide ; fusicogigantones A and B ; pleuroziol

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(90)85196-M

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Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan

Kondo, K. ; Umemoto, A. ; Akimoto, S. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 183 (1992), S. 1139-1146

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ISSN: 0006-291X

Keywords: [abr] B.I.; Brinkman index ; [abr] PCR; polymerase chain reaction ; [abr] RT; reverse transcription ; [abr] SSCP; single strand conformation polymorphism

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0006-291X(05)80309-2

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Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan

Kondo, K. ; Umemoto, A. ; Akimoto, S. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 183 (1992), S. 1139-1146

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ISSN: 0006-291X

Keywords: [abr] B.I.; Brinkman index ; [abr] PCR; polymerase chain reaction ; [abr] RT; reverse transcription ; [abr] SSCP; single strand conformation polymorphism

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0006-291X(05)80309-2

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Diagnosis of the first Japanese patient with 3-oxo-δ 4-steroid 5β-reductase deficiency by use of immunoblot analysis (1998)

Kimura, A. ; Kondo, K.-H. ; Okuda, K.-I. ; [et al.]

Springer

European journal of pediatrics 157 (1998), S. 386-390

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ISSN: 1432-1076

Keywords: Key words 3-Oxo-Δ4-steroid 5β-reductase deficiency ; 3-oxo-Δ4 bile acid ; Immunoblot analysis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract A 3-oxo-Δ4-steroid 5β-reductase (5β-reductase) deficiency is difficult to diagnose because severe liver damage can result in a similar pattern of metabolite excretion. We investigated the usefulness of immunoblot analysis for diagnosis of 5β-reductase deficiency and quantitatively analysed urinary bile acids by gas chromatography-mass spectrometry in a 5-month-old Japanese boy with severe neonatal cholestasis associated with hypertyrosinaemia. A liver sample was examined by immunoblot analysis using monoclonal antibodies against 5β-reductase. Urinary 3-oxo-Δ4 bile acids accounted for 88.3% of total bile acids, 5α-bile acids for 0.9%, and primary bile acids for 9.1%. Immunoblot analysis of the liver tissue showed an indistinct band of 5β-reductase. Conclusions These findings suggest that this patient had a secondary 5β-reductase deficiency due to severe liver damage, even though 3-oxo-Δ4 bile acids constituted more than 70% of total urinary bile acids. However, the patient may possibly have had an inherited 5β-reductase deficiency.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004310050835

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