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  • 1
    Electronic Resource
    Electronic Resource
    Extensive carboxypeptidase digestion of clam α-paramyosin. The effect on the size and solubility of the residual protein
    Amsterdam : Elsevier
    BBA - Protein Structure 577 (1979), S. 410-414 
    Details
    ISSN: 0005-2795
    Keywords: (Clam) ; Carboxypeptidase digestion ; Muscle protein ; Protein solubility ; α-Paramyosin cleavage
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2795(79)90045-X
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of the clonidine-suppression test in the diagnosis of pheochromocytoma (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 764-767 
    Details
    ISSN: 1432-1440
    Keywords: Catecholamines ; Clonidine ; Pheochromocytoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study we examined the preoperative value of the clonidine-suppression test in 15 patients with surgically proved pheochromocytomas. The result of the clonidine-suppression test was pathological (epinephrine plus norepinephrine above 500 ng/l 3 h after clonidine) in 10 of 15 patients (66%). These patients had relatively large tumors and higher basal norepinephrine plasma levels. Out of the 5 cases without a pathological clonidine test 4 had normal basal plasma catecholamine levels with the result that the clonidine test could not be properly applied and 1 case produced a false negative result. These 5 cases generally had smaller tumors and lower plasma catecholamine levels. Two of these cases had basally raised epinephrine values. The other three cases had either a paradoxical increase or a suspiciously low fall (less than 25%) in norepinephrine within the normal range. We conclude that the clonidine-suppression test is only reliable for the diagnosis of relatively large pheochromocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726574
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of131I-metaiodobenzylguanidine scintigraphy with urinary and plasma catecholamine determinations in the diagnosis of pheochromocytoma (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 627-630 
    Details
    ISSN: 1432-1440
    Keywords: Pheochromocytoma ; Catecholamines ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a retrospective study of 31 patients with suspected pheochromocytoma we examined the preoperative results of131I-metaiodobenzylguanidine (131-I-MIBG) scintigraphy and a fluorimetric urine catecholamine determination test. An additional radioenzymatic plasma catecholamine determination test was performed in 25 patients. In 14 of the 31 patients the diagnosis of pheochromocytoma was later histologically confirmed. In the remaining 17 patients the suspected diagnosis was finally rejected after a clinical decision had been made on the basis of clinical history, symptoms, laboratory and imaging tests. 131-I-MIBG scintigraphy apparently had a very high specificity (no false-positive results among the patients with rejected diagnosis), but showed the least sensitivity (3 of 14 tumours were not detected). Urine cate-cholamines showed two false-negative and three false-positive results. Plasma catecholamines had the highest sensitivity and gave only one false-positive result. Because of its high pathognomonic value 131-MIBG scintigraphy can be helpful not only for localization, but also for confirmation of diagnosis when catecholamine determination tests are contradictory. On the basis of our experience with false-positive results after interfering medication therapy, urine and plasma catecholamine determination tests should only be carried out after purification with thin layer chromatography or high performance liquid chromatography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732857
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  • 4
    Electronic Resource
    Electronic Resource
    Notiz über eine einfache Methode zur Darstellung von Niccelocen und Cobaltocen (1962)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 95 (1962), S. 3084-3085 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19620951236
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  • 5
    Electronic Resource
    Electronic Resource
    Das Propin/Propadien-Gleichgewicht (1959)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 92 (1959), S. 1055-1062 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Gleichgewichtslage der Isomerisierungsreaktion Propin ⇌ Propadien wurde im Temperaturbereich von 100 bis 370° unter Zuhilfenahme der Infrarotspektroskopie ermittelt.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19590920508
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  • 6
    Electronic Resource
    Electronic Resource
    Neue polyimidazoloneHerrn Prof. Dr. W. Kern mit den besten Wünschen zum 70. Geburtstag gewidmet (1976)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 177 (1976), S. 1687-1693 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Heat-resistant polyimidazolones were prepared by a two-step polycondensation of α-hydroxy ketones, aromatic diamines, and aromatic diisocyanates. By variation of the reactants several polymers of this type were prepared and their properties are described. Flexible films were cast from solution and parts were produced by moulding at 350°C.
    Notes: In einer zweistufigen Polykondensationsreaktion wurden aus α-Hydroxyketonen, aromatischen Diaminen und aromatischen Diisocyanaten hochtemperaturbeständige Polyimidazolone hergestellt. Durch Variation der Ausgangskomponenten wurde eine Reihe von Polymeren dieser Verbindungsklasse erhalten und in ihren Eigenschaften beschrieben. Aus Lösung wurden Filme gegossen, durch Heißpressen bei 350°C Formkörper hergestellt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1976.021770606
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  • 7
    Electronic Resource
    Electronic Resource
    Über das Schwefelmonoxyd. 2. Mitteilung. Darstellung und Eigenschaften von reinem Schwefelmonoxyd (1933)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 214 (1933), S. 33-43 
    Details
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Darstellung von reinem Schwefelmonoxyd bei höheren Drucken wird beschrieben und seine stöchiometrische Zusammensetzung durch Elementaranalyse der Formel SO entsprechend ermittelt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19332140105
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  • 8
    Electronic Resource
    Electronic Resource
    Structure model of a complex between the factor for inversion stimulation (FIS) and DNA: Modeling protein-DNA complexes with dyad symmetry and known protein structures (1996)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 25 (1996), S. 486-500 
    Details
    ISSN: 0887-3585
    Keywords: protein-DNA interaction ; DNA bending ; helix-turn-helix ; Poisson-Boltzmann electrostatics ; docking ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A method is presented to predict overall conformations of protein-DNA complexes on the basis of the known three-dimensional structures of the proteins. The method is restricted to proteins with a common twofold symmetry axis, which show only minor conformational changes upon binding to DNA. The method uses a numerical finite difference solution of the linearized Poisson-Boltzmann equation and subsequent energy minimization cycles. Structural parameters - the rotation angle of the DNA relative to the protein around the common symmetry axis, the protein-DNA distance, and intermolecular hydrogen-bonding contacts - are presented for two test cases, DNA bound to CAP (catabolite gene activator protein) and to the Cro-repressor of bacteriophage 434. The DNA curvature in the starting model of the docking procedure was chosen as a smoothed approximation of the conformation found in the X-ray structures of these complexes. The method is further used to predict the unknown structure of the complex between the factor for inversion stimulation (FIS) and DNA, which is bent upon binding to FIS. In contrast to the test cases, the unknown curvature of the starting model is derived from a calibration of electrostatic precalculations for different proteins according to crystallographically observed DNA bending. The results of the modeling are in good accordance with the experimentally observed overall structure of protein-DNA complexes for the two test cases; for FIS, they correspond to several of the experimentally proposed protein-DNA contacts. © 1996 Wiley-Liss, Inc.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.8
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  • 9
    Electronic Resource
    Electronic Resource
    Affinity partitioning: Development of mathematical model describing behavior of biomolecules in aqueous two-phase systems (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 30 (1987), S. 514-520 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A mathematical model describing the affinity partitioning of macromolecules in aqueous two-phase systems has been derived. The model was used to calculate binding parameters that were compared against values deter mined by means of ultracentrifugation and fluorescence titration. The mathematical model and its modifications were found to describe satisfactorily the partition behavior of macromolecules with differing numbers of binding sites. It could be shown that in solutions containing PEG the binding behavior of FDH is changed fundamentally. The dissociation constants of FDH with PEG-blue in the presence and absence of PEG are different.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260300408
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  • 10
    Electronic Resource
    Electronic Resource
    Molecular conductors from neutral heterocyclic π-radicals (1994)
    Weinheim : Wiley-Blackwell
    Advanced Materials 6 (1994), S. 798-802 
    Details
    ISSN: 0935-9648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/adma.19940061021
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