ISSN:
1432-0428
Keywords:
Key words Interferon gamma
;
gene
;
polymorphism
;
association
;
insulin dependent diabetes mellitus
;
susceptibility
;
Japanese.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Cytokines may play importmant roles in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). We analysed a dinucleotide repeat polymorphism within the first intron of the interferon γ (IFN-γ ) gene in Japanese diabetic patients (175 IDDM and 145 non-insulin-dependent diabetes mellitus) and 267 control subjects. A significant difference was observed in the global allele distribution of the polymorphism between the IDDM and control groups (p = 0.039). The difference from the control group was more evident in the patients whose insulin therapy started within 1 year from onset (p = 0.006) or in the young-onset (〈 10 years) patients (p = 0.0006). The alleles “3” and “6” were increased in the IDDM patients, and a significant increase in the frequency of the “3/6” genotype was observed in the IDDM patient group (9.1 %, RR 2.9, p = 0.010), in the patients with initial insulin therapy less than 1 year from onset (10.6 %, RR 3.4, p = 0.004), or in the young-onset patients (16.7 %, RR 5.7, p = 0.0003) in comparison to the control subjects (3.4 %). There was a tendency towards frequent occurrence of clinical characteristics which reflect young or abrupt onset of diabetes or both, and depletion of insulin secretion capacity in the patients with “3/6” or “6/6” in comparison to the patients with other genotypes. These results suggest that the IFN-γ gene region may contribute to the pathogenesis of IDDM and could be a genetic marker for IDDM. [Diabetologia (1994) 37: 1159–1162]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00418381
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