ISSN:
1432-0584
Keywords:
Key words Multiple myeloma
;
Prognostic factor
;
Morphology
;
Elderly
;
Young
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The prognostic value of morphological classifications and clinical variables was compared between 31 elderly (≥65 years) and 43 young (〈65 years) patients with myeloma. Prognostic factors were divided into three groups: factors useful in elderly patients, e.g., calcium, albumin; factors useful in young patients, e.g., platelet, creatinine, light-chain type; and factors useful in both patients, e.g., clinical stage, hemoglobin, LDH, CRP, bone marrow plasma cell and plasmablast percentages, light- and electron-microscopic classifications. The 5-year survival rates of elderly patients with calcium 〈12 and ≥12 mg/dl were 66.2 and 〈11.1%, respectively (p〈0.01). Those of the young patients were 64.1 and 33.3%, respectively. The 5-year survival rates of elderly patients with platelets ≥200×109/l and 〈100×109/l were 59.7 and 50.0%, respectively. Those of the young patients were 68.9 and 33.3%, respectively (p〈0.05). The 5-year survival rates of elderly patients with few and numerous electron-microscopic abnormalities were 90 and 0%, respectively (p〈0.01), those of young patients were 92.9 and 〈14.3%, respectively (p〈0.01). These findings suggest that individual clinical variables may differ in prognostic importance in elderly and young patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002770050466
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