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  • Chemical Engineering  (13)
  • Analytical Chemistry and Spectroscopy  (3)
  • (Human)  (2)
  • Cytochrome P450  (2)
  • 1
    Electronic Resource
    Electronic Resource
    A metastable ion study of the electron impact fragmentation of some substituted 2,6-pyrido-containing crown ethers (1987)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 22 (1987), S. 633-636 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Extensive networks of metastable ions link the major peaks in the electron impact mass spectra of two crown ethers containing 2,6-pyrido units. High-resolution mass measurements and the metastable peaks allow the elucidation of the fragmentation pathways. The spectra are influenced more by the presence of aromatic substituents than by the 2,6-pyrido units.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210220911
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  • 2
    Electronic Resource
    Electronic Resource
    Hb F-Forest Park, a new ^Aγ variant with two amino acid substitutions, 75(E19)Ile -〉 Thr and 73(E17)Asp -〉 Asn, which can be identified in adults by gene-mapping analysis
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 832 (1985), S. 242-247 
    Details
    ISSN: 0167-4838
    Keywords: (Human) ; Amino acid substitution ; Gene mapping ; Hemoglobin variant ; Reverse-phase HPLC
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(85)90256-0
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 1218 (1994), S. 48-54 
    Details
    ISSN: 0167-4781
    Keywords: (Human) ; Aromatase ; Aromatase expression ; Phorbol ester
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4781(94)90099-X
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer
    Amsterdam : Elsevier
    Mutation Research DNAging 295 (1993), S. 201-222 
    Details
    ISSN: 0921-8734
    Keywords: Caloric restriction ; Cytochrome P450 ; Drug metabolism
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-8734(93)90021-T
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  • 5
    Electronic Resource
    Electronic Resource
    Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters (1996)
    Springer
    Archives of toxicology 70 (1996), S. 202-208 
    Details
    ISSN: 1432-0738
    Keywords: Key words Diabetes ; Cytochrome P450 ; Monooxygenase ; Hamster ; Streptozotocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The acute and chronic effects of streptozotocin diabetes on kidney and liver microsomal monooxygenases were studied using hamsters 2 days and 6 weeks following treatment with the diabetogen, respectively. Acute diabetes increased aniline hydroxylation and N-nitrosodimethylamine demethylation, decreased pentoxyresorufin O-dealkylation, without affecting benzo(a)pyrene hydroxylation and 7-ethoxycoumarin O-deethylation in kidney and liver microsomes. The effects of chronic diabetes on the microsomal monooxygenases were similar to the effects of acute diabetes, except that the chronic diabetic condition markedly decreased benzo(a)pyrene and 7-ethoxycoumarin oxidations in kidney microsomes. Total cytochrome P450 content and NADPH-cytochrome P450 reductase activity in kidney and liver microsomes of the diabetic hamsters were similar to the controls. Gel electrophoresis of microsomes from control and streptozoptocin treated hamster tissues revealed that diabetes enhanced the intensity of protein band(s) in the P450 molecular weight region. Immunoblotting of microsomal proteins showed that acute and chronic streptozotocin diabetes induced proteins immunorelated to P450s 2E1 and 1A in kidney and liver. In marked contrast, the acute and chronic diabetic conditions decreased the level of a P450 2B-immunorelated protein(s) in kidney and liver. The present study demonstrates that acute and chronic streptozotocin diabetes has the ability to induce P450 2E1 and 1A and suppress P450 2B in hamster kidney and liver and that the hamster monooxygenase responds to diabetes differently from the rat enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050261
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitative analysis of the molecular species of monosialogangliosides by continuous-flow fast-atom bombardment mass spectrometry (1991)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 5 (1991), S. 618-621 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Negative-ion continuous-flow fast-atom bombardment mass spectroemtry was evaluated asa means for the quantitative analysis of N-acetylneuraminyl-galactosyl-glucosyl ceramide (NeuAc-GM3) and N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide (NeuAc-GM3). This study was carried out on a 7070-EQ mass spectrometer (VG Analytical, Manchester, UK) using a home-made continuous-flow fast-atom bombardment probe with a mixture of methanol +water+triethanolamine (70:27:3, v/v/v)as the mobile phase. Utilizing 100 ng of acetyl-lysogalactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosylceramide (acetyl-lysoGM1) as an internal standard curves for NeuAc-GM3 d18:1-16 0, NeuAc-GM3 d18:1-18:0 and Neuac-GM3 d18:1-18:0 were found to be linear over the range 5-250ng, with associated correlation coefficients of 0.990-0.997. The lower limit of detection was found to be 2.5ng. Satisfactory results could also de obtained when the calibration curves were derived from the deprotonated molecular ions of a mixture of the NeuAc-M2 and NeuAc-GM3 classes. Using this approach, quantitative determination of NeuAc-GM3 d18:1-16:0 from rat adrenal gland was performed sing N-acetylneuraminic acid assay as a test control. We found 278±36 ng of this species in 1 mg of tissue (three replicate experiments). The procedure represents a senstive method for the quantitation of mionosialogangliosides and its capability to give molecular species information.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290051210
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  • 7
    Electronic Resource
    Electronic Resource
    Numerical simulation of semicrystalline polymer flowing in an empty tube with solidification (1992)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 32 (1992), S. 724-731 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A methodology is set forth for the numerical solution of the transient freezing problem of a viscous power-law fluid flowing in a cold empty tube with a frozen layer forming on the inside tube surface. The fluid considered is the melt of a semicrystalline polymer with temperature dependent viscosity. The solution domain encompasses both the liquid and solid phases. Coordinate transformations are employed to immobilize and to straighten the moving, curved interface. An implicit finite difference method is employed to solve the governing equations. Numerical results are analyzed by examining the effects of the Peclet number, Nahme number, Stefen number, and the power law index on the profiles of the frozen layer. Variations of the thickness of the frozen layer as a function of time and axial coordinate are also presented.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760321104
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  • 8
    Electronic Resource
    Electronic Resource
    Fickian diffusion of alkanes through glassy polymers: Effects of temperature, diffusant size, and polymer structure (1980)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 20 (1980), S. 40-50 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Diffusivities D ranging over six orders of magnitude with values as low as 2 × 10-13 cm2/s have been obtained by a recently developed permeation apparatus, employing a gas-flow method and a flame ionization detector; Log D for hydrocarbons in bisphenol-A polycarbonate (PC) at 120°C is proportional to the square of the molecular diameter (d2) as given by the Lennard-Jones 6-12 potential. This correlation holds even for the nonspherical n-hexane molecule. The activation energy for diffusion is also linearly related to d2, with values of 9.5 and 23 kcal/mol for methane and neopentane in PC, respectively. Comparison of PC with two similar polymers of higher glass-transition temperatures (Tg) indicates that our diffusion data do not correlate with the Tg of these polymers. The presence of subsidiary transitions, however, appears to enhance segmental mobilities, increasing the rate of diffusion of the hydrocarbons. The thermodynamic solubility of alkanes in glassy PC can be directly related to their boiling points, and in addition, their enthalpy of solution is linearly related to the heat of condensation of these permeants.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760200108
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  • 9
    Electronic Resource
    Electronic Resource
    Experimental investigation of the polymer melt flow during injection post-filling process (1995)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 41 (1995), S. 2661-2663 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690411217
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  • 10
    Electronic Resource
    Electronic Resource
    Study of polymer melt flow in sequential injection molding process (1996)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 42 (1996), S. 1706-1714 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Experimental studies of polymer melt flow in the filling and post-filling stages of the injection molding process were performed using the sequential injection of transparent and colored polystyrene resin. Effects of fountain flow in the filling stage, geometrical factors caused by edges and corners, as well as flow through contractions and expansions, were identified. Significant polymer melt flow which increases with increased packing pressure was observed in the post-filling process. The melt flow is more concentrated around the gate area than away from the gate. It was also found that the polymer melt flows across the gap center, resulting in partial annihilation of the weld line. Simulations based on the control-volume/finite-element method employed within each gapwise layer combined with the dual-filling-parameter technique were developed to trace the advancements in melt fronts for both skin and core materials. Numerical simulations show reasonable consistency with experimental results in both skin and core material distribution. If the edge effect is taken into account using a shape factor as a geometrical correction, the simulation accuracy is further improved.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690420622
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