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  • Inorganic Chemistry  (6)
  • HLA antigens  (3)
  • plasma membrane  (2)
  • (Kidney)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Sequence analysis of the catalytic subunit of H^+-ATPase from porcine renal brush-border membranes
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 1112 (1992), S. 129-141 
    Details
    ISSN: 0005-2736
    Keywords: (Kidney) ; ATPase, H^+- ; Brush-border membrane ; Catalytic subunit ; Primary structure
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0005-2736(92)90263-L
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  • 2
    Electronic Resource
    Electronic Resource
    HLA frequencies and haplotypes in children with idiopathic thrombocytopenic purpura (ITP) (1978)
    Springer
    European journal of pediatrics 129 (1978), S. 267-272 
    Details
    ISSN: 1432-1076
    Keywords: HLA antigens ; Idiopathic thrombocytopenic purpura
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 26 patients with an acute reversible ITP and 6 with chronic ITP were tissue typed, together with their healthy first-degree relatives. The HLA frequencies of the different groups were compared with those of a normal control population. The only significant difference between the groups was an increase in the frequency of Aw32 in acute ITP patients. HLA-Aw32 was present in 26.9% of patients, but in only 0.8% of the controls (corrected P=0.000027). The possible importance of associations between antigens of the HLA-A locus with certain diseases are discussed. Family analyses and haplotype determinations proved to be unproductive because no familial clustering of ITP was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441357
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  • 3
    Electronic Resource
    Electronic Resource
    HLA frequencies in primary immunodeficiency diseases (PIDD) (1977)
    Springer
    European journal of pediatrics 124 (1977), S. 199-205 
    Details
    ISSN: 1432-1076
    Keywords: HLA antigens ; Primary immunodeficiency diseases ; Immune response genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirteen patients with primary immunodeficiency disorders and their twenty-five healthy first-degree relatives were tissue typed and their HLA make-up was compared with that of a normal control population. HLA-A2 occurred in 92.3% of patients as opposed to 60.8% in the control group (P〈0.02), HLA-A9 in 7.6% vs. 25% (P〈0.02) and HLA-B8 in 0% vs. 21% (P〈0.04). One of the patients with severe combined immunodeficiency showed one “extraneous” HLA specifity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00452111
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  • 4
    Electronic Resource
    Electronic Resource
    Lack of association between HLA specificities and Wilm's tumour (1981)
    Springer
    European journal of pediatrics 136 (1981), S. 47-49 
    Details
    ISSN: 1432-1076
    Keywords: HLA antigens ; Wilms' tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract HLA antigen distribution was determined in thirty patients with Wilms' tumour, and their frequencies compared with those of an ethnically matched control population. No statistically significant association was found between any single HLA antigen and Wilms' tumour disease. The value of prospective HLA typing studies, with special respect to genetic aspects, histopathological subgrouping and survival rate of Wilms' tumour patients is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441710
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  • 5
    Electronic Resource
    Electronic Resource
    Electrogenic calcium transport in plasma membrane of rat pancreatic acinar cells (1985)
    Springer
    The journal of membrane biology 84 (1985), S. 45-60 
    Details
    ISSN: 1432-1424
    Keywords: electrogenic Ca2+ transport ; plasma membrane ; rough endoplasmic reticulum ; pancreatic acinar cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary ATP-dependent45Ca2+ uptake was investigated in purified plasma membranes from rat pancreatic acinar cells. Plasma membranes were purified by four subsequent precipitations with MgCl2 and characterized by marker enzyme distribution. When compared to the total homogenate, typical marker enzymes for the plasma membrane, (Na+,K+)-ATPase, basal adenylate cyclase and CCK-OP-stimulated adenylate cyclase were enriched by 43-fold, 44-fold, and 45-fold, respectively. The marker for the rough endoplasmic reticulum was decreased by fourfold compared to the total homogenate. Comparing plasma membranes with rough endoplasmic reticulum, Ca2+ uptake was maximal with 10 and 2 μmol/liter free Ca2+, and half-maximal with 0.9 and 0.5 μmol/liter free Ca2+. It was maximal at 3 and 0.2 mmol/liter free Mg2+ concentration, at an ATP concentration of 5 and 1 mmol/liter, respectively, and at pH 7 for both preparations. When Mg2+ was replaced by Mn2+ or Zn2+ ATP-dependent Ca2+ uptake was 63 and 11%, respectively, in plasma membranes; in rough endoplasmic reticulum only Mn2+ could replace Mg2+ for Ca2+ uptake by 20%. Other divalent cations such as Ba2+ and Sr2+ could not replace Mg2+ in Ca2+ uptake. Ca2+ uptake into plasma membranes was not enhanced by oxalate in contrast to Ca2+ uptake in rough endoplasmic reticulum which was stimulated by 7.3-fold. Both plasma membranes and rough endoplasmic reticulum showed cation and anion dependencies of Ca2+ uptake. The sequence was K+〉Rb+〉Na+〉Li+〉choline+ in plasma membranes and Rb+≥K+≥Na+〉Li+〉choline+ for rough endoplasmic reticulum. The anion sequence was Cl−≥Br−≥I−〉SCN−〉NO 3 − 〉isethionate− 〉cyclamate−〉gluconate−〉SO 4 2− ≥glutarate− and Cl−〉Br〉gluconate〉SO 4 2− 〉NO 3 − 〉I−〉cyclamate−≥SCN−, respectively. Ca2+ uptake into plasma membranes appeared to be electrogenic since it was stimulated by an inside-negative K+ and SCN diffusion potential and inhibited by an inside-positive diffusion potential. Ca2+ uptake into rough endoplasmic reticulum was not affected by diffusion potentials. We assume that the Ca2+ transport mechanism in plasma membranes as characterized in this study represents the extrusion system for Ca2+ from the cell that might be involved in the regulation of the cytosolic Ca2+ level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01871647
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  • 6
    Electronic Resource
    Electronic Resource
    Na+/Ca2+ countertransport in plasma membrane of rat pancreatic acinar cells (1985)
    Springer
    The journal of membrane biology 87 (1985), S. 107-119 
    Details
    ISSN: 1432-1424
    Keywords: Na+/Ca2+ countertransport ; plasma membrane ; pancreatic acinar cells ; amiloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The presence of a coupled Na+/Ca2+ exchange system has been demonstrated in plasma membrane vesicles from rat pancreatic acinar cells. Na+/Ca2+ exchange was investigated by measuring45Ca2+ uptake and45Ca2+ efflux in the presence of sodium gradients and at different electrical potential differences across the membrane (=Δϕ) in the presence of sodium. Plasma membranes were prepared by a MgCl2 precipitation method and characterized by marker enzyme distribution. When compared to the total homogenate, the typical marker for the plasma membrane, (Na++K+)-ATPase was enriched by 23-fold. Markers for the endoplasmic reticulum, such as RNA and NADPH cytochromec reductase, as well as for mitochondria, the cytochromec oxidase, were reduced by twofold, threefold and 10-fold, respectively. For the Na+/Ca2+ countertransport system, the Ca2+ uptake after 1 min of incubation was half-maximal at 0.62 μmol/liter Ca2+ and at 20 mmol/liter Na+ concentration and maximal at 10 μmol/liter Ca2+ and 150 mmol/liter Na+ concentration, respecitively. When Na+ was replaced by Li+, maximal Ca2+ uptake was 75% as compared to that in the presence of Na+. Amiloride (10−3 mol/liter) at 200 mmol/liter Na+ did not inhibit Na+/Ca2+ countertransport, whereas at low Na+ concentration (25 mmol/liter) amiloride exhibited dose-dependent inhibition to be 62% at 10−2 mol/liter. CFCCP (10−5 mol/liter) did not influence Na+/Ca2+ countertransport. Monensin inhibited dose dependently; at a concentration of 5×10−6 mol/liter inhibition was 80%. A SCN− or K+ diffusion potential (=Δϕ), being positive at the vesicle inside, stimulated calcium uptake in the presence of sodium suggesting that Na+/Ca2+ countertransport operates electrogenically, i.e. with a stoichiometry higher than 2 Na+ for 1 Ca2+. In the absence of Na+, Δϕ did not promote Ca2+ uptake. We conclude that in addition to ATP-dependent Ca2+ outward transport as characterized previously (E. Bayerdörffer, L. Eckhardt, W. Haase & 1. Schulz, 1985,J. Membrane Biol. 84:45–60) the Na+/Ca2+ countertransport system, as characterized in this study, represents a second transport system for the extrusion of calcium from the cell. Furthermore, the high affinity for calcium suggests that this system might participate in the regulation of the cytosolic free Ca2+ level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870657
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  • 7
    Electronic Resource
    Electronic Resource
    Über die Einwirkung von Ozon auf wäßrige, kolloide Lösungen anorganischer Stoffe (1925)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 147 (1925), S. 188-195 
    Details
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1. Silbersol wird durch Ozon unter Silberhydroxydbildung schnell gelöst, aus Quecksilbersol wird Quecksilberoxydul ausgeflockt, Goldsol wird nur teilweise gelöst, die rote Farbe des Soles schlägt dabei infolge der Salzwirkung der gelösten Goldverbindungen in Blau um.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19251470118
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  • 8
    Electronic Resource
    Electronic Resource
    Ba5[CrN4]N: Das erste Nitridochromat(V) (1995)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 621 (1995), S. 511-515 
    Details
    ISSN: 0044-2313
    Keywords: Nitridochromate(V) ; preparation ; crystal structure ; magnetic properties ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Ba5[CrN4]N: The First Nitridochromate(V)Ba5[CrN4]N is prepared by reaction of mixtures of Li3N, Ba3N2 and CrN/Cr2N (1 : 1) (molar ratio Li : Ba : Cr = 3 : 5 : 1) in tantalum crucibles at 700°C with flowing nitrogen (1 atm) within a period of 48 h. After cooling down to room temperature (60°C/h) black-shining single crystals of the ternary phase with a platy habit are obtained (monoclinic, C2/m; a = 1054.0(2) pm, b = 1170.9(3) pm, c = 937.7(2) pm, b̃ = 110,79(2)°; Z = 4). The crystal structure contains isolated complex anions [CrVN4]7- which nearly satisfy the ideal tetrahedral symmetry (Cr—N [pm]: 2 × 175.3(4), 2 × 175.8(5); N—Cr—N [°]: 106.8(2), 109.5(2), 2 × 109.9(2), 2 × 110,3(2)). The coordination sphere for each of the terminal nitride functions of the complex anions is completed by five neighbouring Ba2+ ions (distorted CrBa5 octahedra). The octahedra are connected via common CrBa2 faces as well as CrBa edges thereby forming condensed tetrameric octahedral groups. The isolated nitride ions which are also present in the crystal structure of Ba5[CrN4]N are in an octahedral environment of Ba2+ ions.The presence of a d1-System (Cr(V)) is confirmed by magnetic susceptibility data.
    Notes: Ba5[CrN4]N wird durch Umsetzung von Mischungen aus Li3N, Ba3N2 und CrN/Cr2N (1 : 1) im molaren Verhältnis Li: Ba: Cr = 3 : 5 : 1 bei 700°C im Tantaltiegel unter strömendem Sticksktoff (1 atm) dargestellt. Die Reaktionszeit beträgt 48 h. Nach Abkühlen auf Raumtemperatur (60°C/h) liegt die ternäre Phase in Form schwarz-glänzender Kristalle mit plattigem Habitus vor (monoklin, C2/m; a = 1054,0(2) pm, b = 1170,9(3) pm, c = 937,7(2) pm, b̃ = 110,79(2)°; Z = 4). Die Kristallstruktur enthält isolierte komplexe Anionen [CrVN4]7- mit nahezu idealer Tetraedersymmetrie (Cr—N [pm]: 2 × 175,3(4), 2 × 175,8(5); N—Cr—N [°]: 106,8(2), 109,5(2), 2 × 109,9(2), 2 × 110,3(2)). Die Koordinationssphäre der terminalen Nitrid-Funktionen der komplexen Anionen wird durch je fünf benachbarte Ba-Ionen zu verzerrten CrBa5-Oktaedern vervollständigt. Je zwei dieser Oktaeder sind über gemeinsame CrBa2-Flächen zu dimeren Einheiten verknüpft, die über gemeinsame CrBa-Kanten zu tetrameren Oktaedergruppierungen kondensiert sind. Die in der Kristallstruktur von Ba5[CrN4]N zusätzlich enthaltenen, isolierten Nitridionen sind oktaedrisch von Barium umgeben.Das Vorliegen eines d1-Systems (Cr(V)) wird durch Messungen der magnetischen Suszeptibilität belegt.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19956210402
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  • 9
    Electronic Resource
    Electronic Resource
    Die Kristall- und Molekülstruktur von Dicäsium- μ-Oxodekafluorodiarsenat (1973)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 397 (1973), S. 258-268 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Crystal and Molecular Structure of Dicaesium-μ-Oxodecafluorodiarsenate, Cs2(As2F10O)The crystal structure of Cs2(As2F10O) has been determined from three-dimensional data. The compound crystallizes in the monoclinic space group P21/m, the lattice constants being a = 9.175(4), b = 10.690(5), c = 5.619(3)(Å); β = 105,50(5)°.The anion (As2F10O)2- with the point symmetry Cs contains a As—O—As-bridge, whose partial π-bonding is to be discussed. The bond lengths and angles are: As—O: 1.77(2) and 1.68(2) Å, resp., As—O—As: 139(1)°; As…As: 3.225(4) Å, the numbers in parantheses being the standard deviation of the last figure.
    Notes: Die Kristallstruktur der Verbindung Cs2(As2F10O) wurde aus einem dreidimensionalen Datensatz bestimmt. Die Verbindung kristallisiert in der monoklinen Raumgruppe P21/m mit den Gitterdimensionen a = 9,175(4), b = 10,690(5), c = 5,619(3) (Å); β = 105,50(5)°. Das Anion mit der Punktgruppe Cs enthält eine As—O—As-Brücke, für die ein π-Bindungsanteil zu diskutieren ist.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19733970305
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  • 10
    Electronic Resource
    Electronic Resource
    Die Kristall- und MolekülStruktur von Jodo- bis- [2-(diphenylphosphinomethyl)pyridin]nickel(II)-jodid, einem diamagnetischen, quadratisch-pyramidalen Komplex mit d8-Konfiguration (1974)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 404 (1974), S. 273-283 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The Crystal and Molecular Structure of Jodo-bis-[2-(diphenylphosphinomethyl)pyridine]nickel(II)-jodide, which is a Diamagnetic, Square-pyramidal Complex with d8-ConfigurationThe crystal and molecular structure of the title compound has been determined by single-crystal X-ray methods with 5119 independent reflextions and refined to R = 0.061 for 4321 observed reflections. The crystals are monoclinic, space group P21/n, a = 9.016 ± 0.005, b = 21.612 ± 0.012, c = 17.871 ± 0.010 Å, with and β = 96.32 ± 0.15°; Z = 4. The structure was solved by PATTERSON and FOURIER methods and refined by least squares.The molecule cation has approximate Cs-symmetry. The co-ordination around the nickel atom is approximate square pyramidal with two nitrogen and two phosphorus atoms in the basal plane and the jodine atom in the apex. The Ni—J-distance with 3.047(3) Å is very long. In the basal plane, the nitrogen and phosphorus atoms have cis configuration and the geometric arrangements by the two chelate-5-rings are different. The mean Ni—N(1.963(13)Å) and Ni—P(2.166(5)Å) bond lengths are considerably 0.05 longer and 0.10 Å shorter respectively than the corresponding covalent bonding values, derived from the sum of the covalent radii.
    Notes: Die Kristall- und Molekülstruktur der im Titel genannten Verbindung wurde durch eine Röntgenstrukturanalyse an Einkristallen unter Verwendung von 5119 unabhängigen Reflexintensitäten ermittelt. Der R-Wert bei Abschluß der Verfeinerung beträgt für 4321 beobachtete Reflexe 0,061. Die Verbindung kristallisiert in der monoklinen Raumgruppe P21/n mit den Gitterdimensionen a = 9,016 ± 0,005, b = 21,612 ± 0,012, c = 17,871 ± 0,010 Å, β = 96,32 ± 0,15° und 4 Formeleinheiten pro Elementarzelle. Zur Lösung der Struktur wurden PATTERSON- und FOURIER-Synthesen ausgeführt, die Verfeinerung erfolgte durch Kleinste-Quadrate-Berechnungen.Das Molekülkation hat, vereinfachend betrachtet, eine Cs-Pseudosymmetrie. Die Koordination des Nickelatoms ist angenähert als quadratisch-pyramidal mit zwei Stickstoff und zwei Phosphoratomen in der Basisfläche und einem Jodatom in der Spitze aufzufassen. Der Ni—J-Abstand mit 3,047(3) Å ist sehr lang. In der Basisfläche besitzen die Stickstoff und Phosphoratome cis-Konfiguration. Die beiden Chelat-5-Ringe haben unterschiedliche geometrische Gestalt. Die mittleren Ni—N-(1,963(13) Å) und Ni—P-(2,166(5) Å) Bindungsabstände sind 0,05 Å länger bzw. 0,10 Å kürzer als die entsprechenden kovalenten Bindungsabstände, die sich aus der Summe der Kovalenzradien ergeben.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19744040308
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