ISSN:
1432-0533
Keywords:
Proton-Beam Irradiation
;
Isodose Curves
;
Radiation Necrosis
;
Tissue Dose
;
Vulnerability
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In ten patients with intracranial tumor, treatment with proton-beam irradiation was followed by neuropathologic evaluation of autopsy material. Computer-determined isodose curves of radiation dosage aided the correlation of tissue damage with tissue dose of irradiation. Although we found variations in the vulnerability of different anatomic regions (and even within the same region), threshold levels for the effect of proton irradiation were defined. Variables other than tissue dose which determine the extent of damage to the brain include the volume of tissue irradiated, length of time following irradiation, and limitations in our own ability to establish tumor boundaries. Despite these variables, however, tissue reaction and threshold levels following proton-beam irradiation are similar to those of other modalities of radiation therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00691751
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