ISSN:
1432-1912
Schlagwort(e):
Liver Growth
;
Mixed-Function Oxidase
;
Enzyme Induction
;
Enzyme Inhibition
;
Chlorinated Insecticides
;
α-Hexachlorocyclohexane
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary α-hexachlorocyclohexane (α-HCH) elicits liver growth and stimulation of hepatic microsomal mixed-function oxidase. In the present study the extent of these changes was determined in rats 2, 4 and 6 days after treatment with doses of α-HCH ranging from 1 to 600 mg/kg. Above the respective threshold doses liver mass, liver DNA, and the rate of aminopyrine demethylation increased in proportion to the log dose. Threshold doses were calculated to be 30 mg/kg for the increase of liver weight and DNA, and 5 mg/kg for the stimulation of aminopyrine demethylation. Liver mass and liver DNA continued to increase up to the highest dose used; in contrast, the rate of aminopyrine demethylation declined at doses exceeding 200 mg/kg. This decline seems to be due to inhibition by α-HCH retained in the microsomal fraction: α-HCH is a potent, apparently competitive inhibitor of aminopyrine demethylation, and gaschromatographic determinations revealed that the amount of α-HCH retained in the microsomes is sufficient to produce considerable inhibition of the enzymatic reaction.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00501464
Permalink
