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  • 1
    Electronic Resource
    Electronic Resource
    Behandlung des hyperkinetischen Herzsyndroms mit Alinidine und Propranolol (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 69-75 
    Details
    ISSN: 1432-1440
    Keywords: Hyperkinetic heart syndrome ; Bradycardic drugs ; Alinidine (ST 567) ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A hyperkinetic heart syndrome has been diagnosed in 10 patients by clinical investigation and right-heart catheterization at rest and during exercise. Subsequently, the patients received 3×40 mg alinidine, and 2×40 mg propranolol and placebo, each for 2 weeks in a double-blind cross-over study. Heart rate at rest (P〈0.05) and during exercise (P〈0.001) decreased significantly under alinidine and propranolol to the same extent (control, 83/170; alinidine, 68/146; propranolol, 73/139; placebo, 83/162 beats per min). Lower limb flow at rest and after exercise, measured by plethysmography, as well as left-ventricular fractional shortening and mean velocity of circumferential fiber shortening, measured by echocardiography, decreased insignificantly. Sedation and a dry mouth occurred in six patients under alinidine, while fatigue and cold hands and/or feet were reported by five patients under propranolol. Thus, alinidine may be used as an alternative to beta-blocking in the treatment of the hyperkinetic heart syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745476
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of hypophysectomy on the stimulation of liver growth by α-hexachlorocyclohexane, phenobarbital, and partial hepatectomy in the rat (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 298 (1977), S. 137-142 
    Details
    ISSN: 1432-1912
    Keywords: Liver growth ; DNA ; Hypophysis ; α-Hexachlorocyclohexane ; Phenobarbital ; Partial hepatectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary α-Hexachlorocyclohexane (α-HCH) or phenobarbital (PB) elicit growth and cell multiplication in rat liver. In hypophysectomized rats, α-HCH and PB induce an increase in liver mass, but no increase in liver DNA. Hypophysectomy without additional treatment results in a decrease of liver size and RNA, while the DNA content remains unchanged, thereby leading to a relative DNA surplus. 1/3-hepatectomy in hypophysectomized animals leads to a small increase of hepatic DNA only; after 2/3-hepatectomy 75–80% of the original liver DNA are restored. In rats with intact hypophysis losses of liver DNA are known to be restored completely. The findings suggest that the relative DNA surplus in hypophysectomized rats prevents the stimulation of DNA synthesis by weak growth stimuli such as α-HCH, PB, and 1/3-hepatectomy. If the relative DNA surplus is eliminated by partial hepatectomy, the inducers do produce DNA multiplication. It is concluded that the induction of liver growth and cell multiplication by α-HCH and PB does not require the presence of the hypophysis or one of its hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508620
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Liver growth and mixed-function oxidase activity: Dose-dependent stimulatory and inhibitory effects of α-hexachlorocyclohexane (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 285 (1974), S. 355-366 
    Details
    ISSN: 1432-1912
    Keywords: Liver Growth ; Mixed-Function Oxidase ; Enzyme Induction ; Enzyme Inhibition ; Chlorinated Insecticides ; α-Hexachlorocyclohexane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary α-hexachlorocyclohexane (α-HCH) elicits liver growth and stimulation of hepatic microsomal mixed-function oxidase. In the present study the extent of these changes was determined in rats 2, 4 and 6 days after treatment with doses of α-HCH ranging from 1 to 600 mg/kg. Above the respective threshold doses liver mass, liver DNA, and the rate of aminopyrine demethylation increased in proportion to the log dose. Threshold doses were calculated to be 30 mg/kg for the increase of liver weight and DNA, and 5 mg/kg for the stimulation of aminopyrine demethylation. Liver mass and liver DNA continued to increase up to the highest dose used; in contrast, the rate of aminopyrine demethylation declined at doses exceeding 200 mg/kg. This decline seems to be due to inhibition by α-HCH retained in the microsomal fraction: α-HCH is a potent, apparently competitive inhibitor of aminopyrine demethylation, and gaschromatographic determinations revealed that the amount of α-HCH retained in the microsomes is sufficient to produce considerable inhibition of the enzymatic reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501464
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    Paper (German National Licenses)
    Fulltext
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