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  • benzodiazepine antagonist  (2)
  • 05 B 35  (1)
  • End to side anastomosis  (1)
  • Multiple Myeloma  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Flow patterns at the site of extracranial to intracranial end to side anastomosis (1984)
    Springer
    Acta neurochirurgica 73 (1984), S. 45-57 
    Details
    ISSN: 0942-0940
    Schlagwort(e): End to side anastomosis ; flow patterns ; rheological study
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Flow property measurements were performed in a plexiglass model of six various types of end-to-side anastomosis (as clinically shown in extracranial to intracranial arterial bypass surgery). Three anastomoses were made without, another three anastomoses with a ringshaped stenosis restricting the lumen to between 25 and 46% of the cross-section as it occurs clinically by formation of thrombi out of the stitching canals. A rectangular type and two 45 degree oblique types—one directed centrally and one directed peripherally—were tested. Pressure head losses at the site of anastomosis were measured under various circumstances of different anastomoses and different flow speeds along the proximal portion of the middle cerebral artery and the superficial temporal artery. Flow resistance values originated by the different types of anastomoses were expressed in terms of additional recipient vessel length. Differences between different types of anastomoses with and without stenosis were very small and under no circumstances exceeded the equivalent of lengthening the recipient vessel by 2 cm. Theoretically, the optimal type of anastomosis is the oblique and centrally directed version; the worst type is the rectangular form. Practically, however, such differences are not relevant. The explanation for such unexpectedly small differences can rheologically be given by considering the dominating role of blood viscosity under the given circumstances, other variables such as short stenosis and angling of flow playing a secondary role.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01401783
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 115-117 
    Details
    ISSN: 1432-1041
    Schlagwort(e): benzodiazepine antagonist ; Ro 15-1788 ; healthy volunteers ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40±8%, mean±SD). A negligible amount (〈0.2% of the dose) of unchanged drug was recovered in urine. Hepatic elimination was rapid, as shown by a short t1/2 of 0.9±0.2 h, and high total plasma and blood clearances of 691±216 ml/min and 716±199 ml/min, respectively. The fast decline of plasma levels from about 60 to 2 ng/ml accounts for the short-lasting reversal of benzodiazepine-induced sedation by Ro 15-1788.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00553165
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  • 3
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 115-117 
    Details
    ISSN: 1432-1041
    Schlagwort(e): benzodiazepine antagonist ; Ro 15-1788 ; healthy volunteers ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40±8%, mean±SD). A negligible amount (〈0.2% of the dose) of unchanged drug was recovered in urine. Hepatic elimination was rapid, as shown by a short t1/2 of 0.9±0.2 h, and high total plasma and blood clearances of 691±216 ml/min and 716±199 ml/min, respectively. The fast decline of plasma levels from about 60 to 2 ng/ml accounts for the short-lasting reversal of benzodiazepine-induced sedation by Ro 15-1788.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02395217
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  • 4
    Digitale Medien
    Digitale Medien
    Intravertebral vacuum phenomenon in multiple myeloma (1987)
    Springer
    Clinical rheumatology 6 (1987), S. 597-599 
    Details
    ISSN: 1434-9949
    Schlagwort(e): Multiple Myeloma ; Osteonecrosis ; Spine ; Radiotherapy ; Vacuum Phenomenon
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Authors report one case of intravertebral vacuum phenomenon associated with a multiple myeloma. Initially, there occurred a collapse and a lysis of the L4 vertebral body. Two months later, after chemotherapy and cobalt-therapy, X-ray examination showed a vacuum cleft phenomenon within the body of L4 and a backward displacement of the L4 posterior wall. At the same time the patient complained of a cruralgia. Recovery occurred after decompression surgery. Histologic sampling of the L4 vertebral body revealed bone necrosis without any abnormal plasmocytosis. Authors draw attention to the neurological complications occurring in the course of the vertebral necrosis and to the fact that, even in case of multiple myeloma, the occurrence of a transverse vacuum cleft may result from osteonecrosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02330600
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  • 5
    Digitale Medien
    Digitale Medien
    Branchings in rooted graphs and the diameter of greedoids (1988)
    Springer
    Combinatorica 8 (1988), S. 217-234 
    Details
    ISSN: 1439-6912
    Schlagwort(e): 05 B 35 ; 05 c 20 ; 68 Q 20
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract LetG be a 2-connected rooted graph of rankr andA, B two (rooted) spanning trees ofG We show that the maximum number of exchanges of leaves that can be required to transformA intoB isr 2−r+1 (r〉0). This answers a question by L. Lovász. There is a natural reformulation of this problem in the theory ofgreedoids, which asks for the maximum diameter of the basis graph of a 2-connected branching greedcid of rankr. Greedoids are finite accessible set systems satisfying the matroid exchange axiom. Their theory provides both language and conceptual framework for the proof. However, it is shown that for general 2-connected greedoids (not necessarily constructed from branchings in rooted graphs) the maximum diameter is 2r−1.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02122803
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