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  • benzodiazepine antagonist  (2)
  • 05 B 35  (1)
  • Leukemic Synovitis  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 115-117 
    Details
    ISSN: 1432-1041
    Schlagwort(e): benzodiazepine antagonist ; Ro 15-1788 ; healthy volunteers ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40±8%, mean±SD). A negligible amount (〈0.2% of the dose) of unchanged drug was recovered in urine. Hepatic elimination was rapid, as shown by a short t1/2 of 0.9±0.2 h, and high total plasma and blood clearances of 691±216 ml/min and 716±199 ml/min, respectively. The fast decline of plasma levels from about 60 to 2 ng/ml accounts for the short-lasting reversal of benzodiazepine-induced sedation by Ro 15-1788.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00553165
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 115-117 
    Details
    ISSN: 1432-1041
    Schlagwort(e): benzodiazepine antagonist ; Ro 15-1788 ; healthy volunteers ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40±8%, mean±SD). A negligible amount (〈0.2% of the dose) of unchanged drug was recovered in urine. Hepatic elimination was rapid, as shown by a short t1/2 of 0.9±0.2 h, and high total plasma and blood clearances of 691±216 ml/min and 716±199 ml/min, respectively. The fast decline of plasma levels from about 60 to 2 ng/ml accounts for the short-lasting reversal of benzodiazepine-induced sedation by Ro 15-1788.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02395217
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Branchings in rooted graphs and the diameter of greedoids (1988)
    Springer
    Combinatorica 8 (1988), S. 217-234 
    Details
    ISSN: 1439-6912
    Schlagwort(e): 05 B 35 ; 05 c 20 ; 68 Q 20
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract LetG be a 2-connected rooted graph of rankr andA, B two (rooted) spanning trees ofG We show that the maximum number of exchanges of leaves that can be required to transformA intoB isr 2−r+1 (r〉0). This answers a question by L. Lovász. There is a natural reformulation of this problem in the theory ofgreedoids, which asks for the maximum diameter of the basis graph of a 2-connected branching greedcid of rankr. Greedoids are finite accessible set systems satisfying the matroid exchange axiom. Their theory provides both language and conceptual framework for the proof. However, it is shown that for general 2-connected greedoids (not necessarily constructed from branchings in rooted graphs) the maximum diameter is 2r−1.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02122803
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  • 4
    Digitale Medien
    Digitale Medien
    Knee arthritis revealing acute leukemia in a patient with rheumatoid arthritis (1991)
    Springer
    Clinical rheumatology 10 (1991), S. 76-77 
    Details
    ISSN: 1434-9949
    Schlagwort(e): Synovitis ; Acute Leukenia ; Leukemic Synovitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We report one case of leukemic synovitis in a patient with a 40-year history of rheumatoid arthritis. The synovial fluid sample and synovial biopsy specimen showed myeloblastic cells. So, leukemic synovitis can be suspected in a patient with inflammatory rheumatism and adequate diagnostic procedures should be carried out.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02208036
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