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1,25-Dihydroxyvitamin D"3 enhances the growth of tumors in athymic mice inoculated with receptor rich osteosarcoma cells

Yamaoka, K. ; Marion, S.L. ; Gallegos, A. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 139 (1986), S. 1292-1298

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ISSN: 0006-291X

Keywords: [abr] 1,25(OH)"2D"3; 1,25-dihydroxyvitamin D"3 ; [abr] 1α(OH)D"3; 1α-hydroxyvitamin D"3 ; [abr] 25(OH)D"3; 25-hydroxyvitamin D"3 ; [abr] KPDMoA-0.3; 0.3 M KC1, 5 mM dithiothreitol 10 mM sodium

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0006-291X(86)80318-7

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1,25-Dihydroxyvitamin D"3 enhances the growth of tumors in athymic mice inoculated with receptor rich osteosarcoma cells

Yamaoka, K. ; Marion, S.L. ; Gallegos, A. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 139 (1986), S. 1292-1298

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ISSN: 0006-291X

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0006-291X(86)80318-7

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Direct influence of antidepressants on GTP binding protein of adenylate cyclase in cell membranes of the cerebral cortex of rats (1988)

Yamaoka, K. ; Nanba, T. ; Nomura, S.

Springer

Journal of neural transmission 71 (1988), S. 165-175

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ISSN: 1435-1463

Keywords: Antidepressant ; adenylate cyclase ; GTP binding protein

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Recently, it has been suggested that antidepressant drugs exert their pharmacological action through functional changes in the adrenergic-receptor coupled adenylate cyclase system. In the present research, we examined the direct effects of antidepressants on adenylate cyclase (A-cyclase) activity by in vitro incubation of cell membranes from the cerebral cortex of rats with these drugs. All antidepressants examined, such as imipramine, clomipramine, amitriptyline, desipramine, mianserin and zimelidine inhibited A-cyclase in a dose dependent manner. Antidepressants did not exert any influence on Mn2+-induced elevation of A-cyclase, but significantly suppressed F−-stimulated A-cyclase activity. GTP-induced elevation of A-cyclase was completely inhibited by prior incubation with antidepressants. Our conclusion, therefore, is that antidepressants may reduce A-cyclase activity not by inhibiting the function of the catalytic unit of A-cyclase, but by supressing the N-protein function.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01245710

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Plasma 1,25-dihydroxyvitamin D concentrations in cords, newborns, infants, and children (1980)

Seino, Y. ; Shimotsuji, T. ; Yamaoka, K. ; [et al.]

Springer

Calcified tissue international 30 (1980), S. 1-3

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ISSN: 1432-0827

Keywords: 1,25-(OH)2-D ; Children ; Newborns

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Summary Plasma 1,25-dihydroxyvitamin D [1,25-(OH)2-D] was measured in cord serum, newborns, infants, and children. The mean for the values obtained from the six cords was significantly higher than the mean for the older children (6–15 years). The mean for the six newborns (0–1 week) was significantly higher than that for the older children. The mean for the nine infants (1 week-6 months) and the 14 younger children (6 months-6 years) was significantly higher than that for older children. The present study suggests that the perinatal period is associated with a marked increase in 1,25-(OH)2-D.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02408599

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Activity of renal 25-hydroxyvitamin D3-1α-hydroxylase in a case of X-linked hypophosphataemic rickets (1984)

Seino, Y. ; Satomura, K. ; Yamaoka, K. ; [et al.]

Springer

European journal of pediatrics 142 (1984), S. 219-222

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ISSN: 1432-1076

Keywords: Hypophosphataemic rickets ; 1,25(OH)2D ; 1α-hydroxylase

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract In 1974, a 2-year-old boy was diagnosed as having X-linked hypophosphataemic rickets (XLH) because of severe rickets and hypophosphataemia. The vitamin D metabolite concentrations, blood and urine chemistry and renal 25-hydroxyvitamin D3 (25 OHD3)-1α-hydroxlase were measured in 1982 (about 2 weeks after withdrawal of medication). 1α-hydroxylase was 392 pg/mg tissue/20 min in the patient, which was high compared with aged-matched controls (69.7±28.5 pg/mg tissue/20 min, mean ±SD, n=7). Our present studies showed that the 1α-hydroxylase activity in the patient with XLH was elevated. Therefore, the normal or low 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) concentrations in XLH patients could be due to accelerated catabolism of 1,25-(OH)2D3 or abnormally regulated 25OHD3-1α-hydroxylase in response to hypophosphataemia, although significantly elevated above that in normal controls.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00442454

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